Chitosan surface modification modulates the mucoadhesive, permeation and anti-angiogenic properties of gellan gum/bevacizumab nanoparticles

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCarvalho, Suzana Gonçalves-
Autor(es): dc.creatorHaddad, Felipe Falcão-
Autor(es): dc.creatordos Santos, Aline Martins-
Autor(es): dc.creatorScarim, Cauê Benito-
Autor(es): dc.creatorFerreira, Leonardo Miziara Barboza-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorGremião, Maria Palmira Daflon-
Data de aceite: dc.date.accessioned2025-08-21T20:47:58Z-
Data de disponibilização: dc.date.available2025-08-21T20:47:58Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2024.130272-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299514-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299514-
Descrição: dc.descriptionBevacizumab (BVZ) was the first monoclonal antibody approved by the FDA and has shown an essential advance in the antitumor therapy of colorectal cancer (CRC), however, the systemic action of BVZ administered intravenously can trigger several adverse effects. The working hypothesis of the study was to promote the modulation of the mucoadhesion properties and permeability of the BVZ through the formation of nanoparticles (NPs) with gellan gum (GG) with subsequent surface modification with chitosan (CS). NPs comprising BVZ and GG were synthesized through polyelectrolyte complexation, yielding spherical nanosized particles with an average diameter of 264.0 ± 2.75 nm and 314.0 ± 0.01 nm, polydispersity index of 0.182 ± 0.01 e 0.288 ± 0.01, and encapsulation efficiency of 29.36 ± 0.67 e 60.35 ± 0.27 mV, for NPs without (NP_BVZ) and with surface modification (NP_BVZ + CS). The results showed a good ability of nanoparticles with surface modification to modulate the NPs biological properties.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceutics School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceutics School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2014/50928-2-
Descrição: dc.descriptionFAPESP: 2019/10761-5-
Descrição: dc.descriptionFAPESP: 2022/14075-1-
Descrição: dc.descriptionCNPq: 465687/2014-8-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAngiogenesis-
Palavras-chave: dc.subjectAntibody-
Palavras-chave: dc.subjectBevacizumab-
Palavras-chave: dc.subjectChitosan-
Palavras-chave: dc.subjectGellan gum-
Palavras-chave: dc.subjectPolymeric nanoparticle-
Título: dc.titleChitosan surface modification modulates the mucoadhesive, permeation and anti-angiogenic properties of gellan gum/bevacizumab nanoparticles-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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