The anterior cingulate cortex and its interface with the dorsal periaqueductal grey regulating nitric oxide-mediated panic-like behaviour and defensive antinociception

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorPsychobiology Division-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBiomedical Sciences Institute of the Federal University of Alfenas (UNIFAL)-
Autor(es): dc.creatorFalconi-Sobrinho, Luiz Luciano-
Autor(es): dc.creatorAnjos-Garcia, Tayllon dos-
Autor(es): dc.creatorRebelo, Macário Arosti-
Autor(es): dc.creatorHernandes, Paloma Molina-
Autor(es): dc.creatorAlmada, Rafael Carvalho-
Autor(es): dc.creatorTanus-Santos, Jose Eduardo-
Autor(es): dc.creatorCoimbra, Norberto Cysne-
Data de aceite: dc.date.accessioned2025-08-21T21:22:35Z-
Data de disponibilização: dc.date.available2025-08-21T21:22:35Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.neuropharm.2023.109831-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299489-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299489-
Descrição: dc.descriptionThe anterior cingulate cortex (ACC) Cg1 (24b) area modulates glutamate-mediated unconditioned fear and antinociception organised by hypothalamus. However, it remains unknown whether 24b area also modulates these latter defensive responses through connections with the dorsal periaqueductal grey matter (dPAG), a midbrain structure implicated in the genesis of innate fear-induced defence. The aim of this work is to examine the correlation between the behavioural effects of intra-ACC microinjections of vehicle, NMDA (1 nmol) or lidocaine (2%) with Fos protein expression and nitrergic activity in the dPAG of male C57BL/6 mice that were threatened by snakes. In addition, the 24b area-dPAG pathways were also characterised by neural tract tracing procedures. Finally, the effect of dPAG pretreatment with the neuronal nitric oxide synthase inhibitor N(omega)-propyl-L-arginine (NPLA; 0.2, 0.4 or 0.8 nmol) 10 min before 24b area treatment with NMDA on behavioural and nociceptive responses of threatened mice was studied. The activation of 24b area N-methyl-D-aspartic acid receptors facilitated escape and freezing rather than risk assessment, and enhanced Fos expression and nitrite levels in dPAG, while lidocaine decreased escape and risk assessment as well as Fos and nitrergic activity in dPAG. In addition, dPAG pretreatment with NPLA suppressed intra-24b NMDA-facilitated panicogenic effects while increased nociception. Infusions of an antegrade neurotracer into 24b area showed axonal fibres surrounding both dorsomedial and dorsolateral PAG perikarya. Neurons were identified in 24b area after deposits of a retrograde neurotracer into dPAG. Our findings suggest that the ACC/24b area modulates innate defensive responses through the recruitment of dPAG nitrergic neurons.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of Neuroanatomy and Neuropsychobiology Department of Pharmacology Ribeirão Preto Medical School of the University of São Paulo (USP), Av. Bandeirantes 3900, Ribeirão Preto-
Descrição: dc.descriptionBehavioural Neurosciences Institute (INeC) Psychobiology Division, Av. Bandeirantes, 3900, Ribeirão Preto-
Descrição: dc.descriptionLaboratory of Cardiovascular Pharmacology Department of Pharmacology Ribeirão Preto Medical School of the University of São Paulo (USP), Av. Bandeirantes 3900, Ribeirão Preto-
Descrição: dc.descriptionLaboratory of Neurobiology and Neurobiotechnology Department of Biological Sciences School of Science São Paulo State University (UNESP), Humanities and Languages, Assis-
Descrição: dc.descriptionBiomedical Sciences Institute of the Federal University of Alfenas (UNIFAL), Minas Gerais-
Descrição: dc.descriptionLaboratory of Neurobiology and Neurobiotechnology Department of Biological Sciences School of Science São Paulo State University (UNESP), Humanities and Languages, Assis-
Descrição: dc.descriptionCNPq: 130124/2012-5-
Descrição: dc.descriptionCNPq: 134267/2013-3-
Descrição: dc.descriptionCNPq: 140857/2021-4-
Descrição: dc.descriptionCNPq: 141124/2014-8-
Descrição: dc.descriptionCNPq: 142030/2020–1-
Descrição: dc.descriptionCNPq: 145258/2015-7-
Descrição: dc.descriptionFAPESP: 2007/01174-1-
Descrição: dc.descriptionFAPESP: 2012/03798-0-
Descrição: dc.descriptionFAPESP: 2012/22681–7-
Descrição: dc.descriptionFAPESP: 2013/10984-8-
Descrição: dc.descriptionFAPESP: 2017/11855-8-
Descrição: dc.descriptionFAPESP: 2017/22647-7-
Descrição: dc.descriptionFAPESP: 2018/03898–1-
Descrição: dc.descriptionFAPESP: 2019/01713–7-
Descrição: dc.descriptionFAPESP: 2019/05255-3-
Descrição: dc.descriptionFAPESP: 2020/15050-7-
Descrição: dc.descriptionFAPESP: 2021/14073-6-
Descrição: dc.descriptionCNPq: 301341/2015-0-
Descrição: dc.descriptionCNPq: 301905/2010-0-
Descrição: dc.descriptionCNPq: 302605/2021-5-
Descrição: dc.descriptionCNPq: 427397/2018-9-
Descrição: dc.descriptionCNPq: 474853/2013-6-
Descrição: dc.descriptionCNPq: 483763/2010-1-
Descrição: dc.descriptionCAPES: PNPD20131680-33002029012P3-
Idioma: dc.languageen-
Relação: dc.relationNeuropharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnterior cingulate cortex-
Palavras-chave: dc.subjectCrotalus durissus terrificus-
Palavras-chave: dc.subjectDefensive behaviour-
Palavras-chave: dc.subjectFear-induced analgesia-
Palavras-chave: dc.subjectNitric oxide-
Palavras-chave: dc.subjectNMDA receptors-
Palavras-chave: dc.subjectPeriaqueductal grey matter-
Título: dc.titleThe anterior cingulate cortex and its interface with the dorsal periaqueductal grey regulating nitric oxide-mediated panic-like behaviour and defensive antinociception-
Tipo de arquivo: dc.typelivro digital-
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