Coconut oil reduces steroidogenic enzymes and imbalances estrogen receptors in the adrenal cortex of Mongolian gerbils

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorGrigio, Vitor-
Autor(es): dc.creatorGuerra, Luiz Henrique Alves-
Autor(es): dc.creatorRuiz, Thalles Fernando Rocha-
Autor(es): dc.creatorTaboga, Sebastião Roberto-
Autor(es): dc.creatorVilamaior, Patrícia Simone Leite-
Data de aceite: dc.date.accessioned2025-08-21T15:32:40Z-
Data de disponibilização: dc.date.available2025-08-21T15:32:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.fct.2025.115248-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299485-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299485-
Descrição: dc.descriptionThis study aims to verify the effects of prolonged ingestion of coconut oil on the adrenal glands of Mongolian gerbils. Mongolian gerbils were used as an experimental model due to the morphological similarity of the adrenal glands to those of primates. Male Mongolian gerbils, 3 months of age, were divided into three experimental groups (n = 12): an intact control group, which received no treatment, a gavage control group, which received 0.1 ml of water daily by gavage, and a coconut oil-treated group, which received 0.1 ml of coconut oil daily for 12 months. The results showed that prolonged consumption of coconut oil caused an increase in cell area and thickness of the zona reticularis and the accumulation of lipid droplets, as well as reducing the amount of steroidogenic enzymes, such as CYP17, 3BHSD, and 17BHSD. It was also observed that the oil increased the expression of estrogen receptor alpha and their isoforms. These alterations allow us to conclude that changes in the lipid diet can cause alterations in the morphophysiology of the adrenal gland and, consequently, impact its functionality.-
Descrição: dc.descriptionDepartment of Biological Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biology University of Campinas (UNICAMP), SP-
Descrição: dc.descriptionDepartment of Biological Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFood and Chemical Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectLipid droplets-
Palavras-chave: dc.subjectPhytotherapies-
Palavras-chave: dc.subjectSteroidogeneses-
Palavras-chave: dc.subjectSteroids-
Palavras-chave: dc.subjectVegetable oil-
Título: dc.titleCoconut oil reduces steroidogenic enzymes and imbalances estrogen receptors in the adrenal cortex of Mongolian gerbils-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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