Saliva culture as a predictive indicator for current blood infections and antimicrobial resistance in the ICU setting

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstituto Policlin de Ensino e Pesquisas-IPEP-
Autor(es): dc.contributorUniversity of Lyon-
Autor(es): dc.contributorUniversité Lyon 1-
Autor(es): dc.contributorAnhembi Morumbi University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorda Rocha Santos, Leonardo Moura Brasil-
Autor(es): dc.creatorde Paula Ramos, Lucas-
Autor(es): dc.creatorSantos, Carlos Eduardo Rocha-
Autor(es): dc.creatorMiranda, Diego Garcia-
Autor(es): dc.creatorGimenez, Mariana Gadelho-
Autor(es): dc.creatorMeccatti, Vanessa Marques-
Autor(es): dc.creatorAbu Hasna, Amjad-
Autor(es): dc.creatordos Santos Oliveira, Marcela-
Autor(es): dc.creatorNeto, Morun Bernardino-
Autor(es): dc.creatorDias de Oliveira, Luciane-
Data de aceite: dc.date.accessioned2025-08-21T19:23:36Z-
Data de disponibilização: dc.date.available2025-08-21T19:23:36Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-023-47143-3-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299481-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299481-
Descrição: dc.descriptionAntimicrobial resistance is a worldwide health problem and patients in intensive care are more vulnerable, requiring strict control measures and early identification. Currently, clinical culture materials are used to identify the bacterial agent, but saliva culture is not validated, which has great clinical relevance because it participates in several pathophysiological processes. The aim of this study was to validate saliva culture in an intensive care unit environment, determining its diagnostic value for infection. For this purpose, the results of the 39-month surveillance cultures, from the database of a private hospital were evaluated. A total of 323 cultures were paired between saliva, tracheal secretions, blood and urine from patients who were hospitalized for more than 5 days. The search for correlations between the results was performed using the Spearman correlation test. Severity and evolution data were also correlated. It was possible to correlate the presence of Klebsiella spp. between blood culture and saliva culture in 25% of the results (r = 0.01) and the correlation between saliva and tracheal secretion was 33% (r = 0.33447) with p < 0.0001. In conclusion, saliva can be an excellent discriminator of systemic infections, and can be considered a useful culture in clinical practice.-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (ICT-UNESP), Francisco José Longo 777, São Dimas, SP-
Descrição: dc.descriptionInstituto Policlin de Ensino e Pesquisas-IPEP, Av. Nove de Julho, 430-Vila Ady’Anna, SP-
Descrição: dc.descriptionLaboratory “Systemic Health Care” EA4129 University of Lyon-
Descrição: dc.descriptionUFR de Médicine Université Lyon 1-
Descrição: dc.descriptionLaboratoire des Multimatériaux et Interfaces CNRS (UMR 5615) Université Lyon 1-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP), Av. Francisco José Longo 777, São Dimas, SP-
Descrição: dc.descriptionAnhembi Morumbi University, Benedito Matarazzo, 6070-Jardim Aquarius, SP-
Descrição: dc.descriptionDepartamento de Ciências Básicas e Ambientais-LOB Escola de Engenharia de Lorena-EEL/USP, Estrada Municipal do Campinho, s/no, SP-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (ICT-UNESP), Francisco José Longo 777, São Dimas, SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP), Av. Francisco José Longo 777, São Dimas, SP-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleSaliva culture as a predictive indicator for current blood infections and antimicrobial resistance in the ICU setting-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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