Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBassetto, Cesar C.-
Autor(es): dc.creatorAlbuquerque, Ana Cláudia A.-
Autor(es): dc.creatorLins, José Gabriel G.-
Autor(es): dc.creatorMarinho-Silva, Naiara M.-
Autor(es): dc.creatorChocobar, Marianna L.E.-
Autor(es): dc.creatorBello, Hornblenda J.S.-
Autor(es): dc.creatorMena, Mateus O.-
Autor(es): dc.creatorNiciura, Simone C.M.-
Autor(es): dc.creatorAmarante, Alessandro F.T.-
Autor(es): dc.creatorChagas, Ana Carolina S.-
Data de aceite: dc.date.accessioned2025-08-21T20:03:54Z-
Data de disponibilização: dc.date.available2025-08-21T20:03:54Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijpddr.2024.100527-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299457-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299457-
Descrição: dc.descriptionHaemonchus contortus and Trichostrongylus colubriformis are the most important gastrointestinal nematodes causing serious losses in sheep production of tropical and subtropical regions. Prophylaxis of gastrointestinal nematode infections is based on anthelmintics use, but their frequent administration selects multiple-resistant parasites. To evaluate how the situation has changed over the last decades, the anthelmintic resistance status of gastrointestinal nematodes in sheep flocks was assessed in the current study and compared to previous surveys. In each one of the 15 flocks evaluated, animals (n ≥ 7) were allocated into at least five groups and treated as follows: 1) untreated control; 2) albendazole; 3) levamisole; 4) ivermectin; and 5) monepantel. If more animals were available, two additional groups were included: 6) closantel, and 7) moxidectin. The faecal egg count reduction test (FECRT) was carried out to evaluate the pre- and post-treatment using the SHINY tool. Haemonchus spp. was the most prevalent nematode from faecal cultures. The mean efficacy of albendazole was 40%. Only in two farms, levamisole presented a relatively high percentage of reduction in the FECRT about 90%, while ivermectin and moxidectin presented the worst mean efficacy of 34% and 21% among all farms, respectively. Like other anthelmintics, closantel demonstrated low efficacy (63%) across all farms evaluated. Monepantel presented an overall mean efficacy of 79%, but it was the only anthelmintic that presented efficacy ≥95%, in five farms. The results revealed that gastrointestinal nematodes with multiple anthelmintic resistance were prevalent in all 15 sheep herds. The research suggests that nematodes are becoming more and more resistant to various anthelmintic compounds, which has made the problem worse. This circumstance highlights the necessity to put into practice sustainable and long-lasting methods to prevent gastrointestinal nematode infections in sheep husbandry.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSoutheast Livestock Unit Brazilian Agricultural Research Corporation (EMBRAPA), SP-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science UNESP, SP-
Descrição: dc.descriptionDepartment of Biodiversity and Biostatistics Institute of Biosciences UNESP, SP-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science UNESP, SP-
Descrição: dc.descriptionDepartment of Biodiversity and Biostatistics Institute of Biosciences UNESP, SP-
Descrição: dc.descriptionFAPESP: 2019/02929-3-
Descrição: dc.descriptionFAPESP: 2020/13972-4-
Descrição: dc.descriptionFAPESP: 2021/03479-1-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal for Parasitology: Drugs and Drug Resistance-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnimal production-
Palavras-chave: dc.subjectEpidemiology-
Palavras-chave: dc.subjectFaecal egg count reduction test-
Palavras-chave: dc.subjectGastrointestinal nematodes-
Palavras-chave: dc.subjectHaemonchus contortus-
Palavras-chave: dc.subjectMultiple resistance-
Título: dc.titleRevisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.