Multiple PDT sessions with chlorin-e6 and LL-37 loaded-nanoemulsion provide limited benefits to periodontitis in rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal da Paraíba (UFPB)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorGarcia de Carvalho, Gabriel-
Autor(es): dc.creatorRodrigues Vieira, Basílio-
Autor(es): dc.creatorde Souza Carvalho, Jhonatan-
Autor(es): dc.creatorBarbosa de Sousa, Frederico-
Autor(es): dc.creatorCerri, Paulo Sergio-
Autor(es): dc.creatorde Oliveira, Kleber Thiago-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorZandim-Barcelos, Daniela Leal-
Autor(es): dc.creatorSpolidorio, Luis Carlos-
Autor(es): dc.creatorPalomari Spolidorio, Denise Madalena-
Data de aceite: dc.date.accessioned2025-08-21T21:10:38Z-
Data de disponibilização: dc.date.available2025-08-21T21:10:38Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pdpdt.2024.104329-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299431-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299431-
Descrição: dc.descriptionBackground: The combination of photodynamic therapy (PDT) and LL-37 has never been tested in an animal study and our research team background suggests this strategy might be a promising alternative to intensify periodontitis resolution. This study aimed to assess the effects of multiple sessions of PDT with chlorin-e6 conjugated to the antimicrobial peptide LL-37 loaded nanoemulsion, as adjunctive therapy in experimental periodontitis in rats. Methods: Experimental periodontitis was induced in 81 rats. After disease establishment, animals were assigned to three groups: SRP (scaling and root planning); SRP + 1PDT, SRP followed by a single PDT session; SRP + 4PDT (n = 27), SRP followed by four PDT sessions at 0, 24, 48 and 72 h after SRP. Animals were subjected to euthanasia at 7, 14 and 28 days, and samples were submitted to osteoclast quantification, immunological and microtomography analysis. Results: All treatments resulted in significant periodontal improvements and there was no significant difference between the groups in both local inflammatory response and healing process. Minimal adjunctive effects could be found for the combined therapy in terms of cytokine levels (IL-1β and IL-10), with no statistical significance. However, the number of TRAP-positive osteoclasts per mm of alveolar bone linear surface for the group treated with PDT sessions was significantly lower than those treated with SRP only. Conclusions: Multiple PDT sessions with chlorin-e6 and LL-37 nanoemulsion as an adjunct to scaling and root planning reduced the presence of osteoclast in the local site but did not contribute towards bone regeneration and IL-1β and IL-10 levels.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Physiology and Pathology São Paulo State University (Unesp), School of Dentistry at Araraquara, São Paulo-
Descrição: dc.descriptionDepartment of Morphology Federal University of Paraíba (UFPB), Paraíba-
Descrição: dc.descriptionDepartment of Morphology and Periatric Dentistry School of Dentistry São Paulo State University (Unesp), School of Dentistry at Araraquara, São Paulo-
Descrição: dc.descriptionDepartment of Chemistry Federal University of São Carlos (UFSCar), São Paulo-
Descrição: dc.descriptionDepartment of Drugs and Medicines International School of Pharmaceuticals Sciences São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Oral Diagnosis and Surgery São Paulo State University (Unesp), School of Dentistry at Araraquara, São Paulo-
Descrição: dc.descriptionDepartment of Physiology and Pathology São Paulo State University (Unesp), School of Dentistry at Araraquara, São Paulo-
Descrição: dc.descriptionDepartment of Morphology and Periatric Dentistry School of Dentistry São Paulo State University (Unesp), School of Dentistry at Araraquara, São Paulo-
Descrição: dc.descriptionDepartment of Drugs and Medicines International School of Pharmaceuticals Sciences São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Oral Diagnosis and Surgery São Paulo State University (Unesp), School of Dentistry at Araraquara, São Paulo-
Descrição: dc.descriptionFAPESP: 2013/07276–1-
Descrição: dc.descriptionFAPESP: 2018/09088–1-
Descrição: dc.descriptionFAPESP: 2018/1654–8-
Descrição: dc.descriptionFAPESP: 2020/0449–3-
Descrição: dc.descriptionFAPESP: 2021/05881–1-
Descrição: dc.descriptionFAPESP: 2023/04020–8-
Idioma: dc.languageen-
Relação: dc.relationPhotodiagnosis and Photodynamic Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectPeriodontitis-
Palavras-chave: dc.subjectPhotodynamic Therapy-
Palavras-chave: dc.subjectPhotosensitizing agents-
Título: dc.titleMultiple PDT sessions with chlorin-e6 and LL-37 loaded-nanoemulsion provide limited benefits to periodontitis in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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