Effects of anodal transcranial direct current stimulation on intracranial compliance in the subacute phase of stroke

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Triângulo Mineiro-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorNascimento, Monalisa Resende-
Autor(es): dc.creatorBernardes, Tiago Soares-
Autor(es): dc.creatorSantos, Kelly Cristina Sousa-
Autor(es): dc.creatorSilva, Gabrielly Fernanda-
Autor(es): dc.creatorBazan, Rodrigo-
Autor(es): dc.creatorSande de Souza, Luciane Aparecida Pascucci-
Autor(es): dc.creatorLuvizutto, Gustavo José-
Data de aceite: dc.date.accessioned2025-08-21T17:54:25Z-
Data de disponibilização: dc.date.available2025-08-21T17:54:25Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.clineuro.2024.108597-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299382-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299382-
Descrição: dc.descriptionObjectives: Transcranial direct current stimulation (tDCS) increases cerebral blood flow. This study evaluated the effects of anodal tDCS (A-tDCS) on intracranial compliance (ICC) in patients with subacute stroke using a non-invasive method. Methods: This was a randomized, proof-of-concept, double-blind, pilot study. Patients with ischemic stroke of the middle cerebral artery (MCA) were divided into the following two groups: 1) A-tDCS in the motor cortex on the affected side for 30 min at 2 mA, and 2) sham tDCS in the motor cortex on the affected side. The primary outcomes were intracranial compliance (P2/P1 ratio and time-to-peak [TTP]) and ICC normalization after the intervention (P2/P1 ratio <1). Secondary outcomes were systolic and diastolic blood pressures, heart rate, and peripheral oxygen saturation. Results: No significant differences were observed in the P2/P1 ratio (P = 0.509) and TTP (P = 0.480) between the groups. However, the A-tDCS group was significantly associated with a normal P2/P1 ratio after intervention (B = 2.583; standard error [SE]: 1.277; P = 0.043; corrected for age and stroke severity). No significant associations were observed between the groups and systolic blood pressure (F = 0.16; P = 0.902), diastolic blood pressure (F = 0.18; P = 0.892), heart rate (F = 0.11; P = 0.950), or peripheral oxygen saturation (F = 0.21; P = 0.750). Conclusion: ICC morphology normalization was observed in the A-tDCS group. However, no differences were observed in the P2/P1 ratio, TTP, or hemodynamic variables between the groups. A sample size of 66 patients with ischemic stroke of the MCA can be estimated using the observed effect size and standard α = 5 % and β = 20 % for future trials. Furthermore, this will aid in conducting the necessary randomized trials targeting these populations.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Applied Physical Therapy Federal University of Triângulo Mineiro, Minas Gerais-
Descrição: dc.descriptionDepartment of Medicine Federal University of Triângulo Mineiro, Minas Gerais-
Descrição: dc.descriptionDepartment of Neurology Psychology and Psychiatry Botucatu Medical School, São Paulo-
Descrição: dc.descriptionDepartment of Neurology Psychology and Psychiatry Botucatu Medical School, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationClinical Neurology and Neurosurgery-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectIntracranial compliance-
Palavras-chave: dc.subjectIntracranial pressure-
Palavras-chave: dc.subjectNon-invasive-
Palavras-chave: dc.subjectStroke-
Palavras-chave: dc.subjectTranscranial direct current stimulation-
Título: dc.titleEffects of anodal transcranial direct current stimulation on intracranial compliance in the subacute phase of stroke-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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