Brazilian red propolis synergistically with imipenem modulates immunological parameters and the bactericidal activity of human monocytes against methicillin-resistant Staphylococcus aureus (MRSA)

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorRipari, Nicolas-
Autor(es): dc.creatorHonorio, Mariana da Silva-
Autor(es): dc.creatorSartori, Arthur Alves-
Autor(es): dc.creatorOliveira, Larissa Ragozo Cardoso de-
Autor(es): dc.creatorBastos, Jairo Kenupp-
Autor(es): dc.creatorSforcin, Jose Mauricio-
Data de aceite: dc.date.accessioned2025-08-21T19:45:10Z-
Data de disponibilização: dc.date.available2025-08-21T19:45:10Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-24-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/jpp/rgae135-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299371-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299371-
Descrição: dc.descriptionObjectives: Propolis is a bee product found all over the globe and has a well-known antibacterial activity. Previous findings of our group revealed that the combination of Brazilian red propolis (BRP) with a lower concentration of imipenem (IPM) exerted a bactericidal action against methicillin-resistant Staphylococcus aureus (MRSA) in vitro. Here, we aimed at investigating the effects of BRP in combination or not with IPM on human monocytes to assess a possible immunomodulatory action. Methods: Monocyte metabolic activity was analysed by MTT assay, cytokine production (TNF-alpha, IL-1 beta, IL-6, IL-8, and IL-10) by ELISA, and the expression of cell markers (TLR-2, TLR-4, HLA-DR, and CD80) by flow cytometry. The bactericidal activity of monocytes over MRSA was determined by colony-forming units' count. Key findings: BRP alone or in combination with IPM exerted no cytotoxic effects on monocytes. BRP downregulated TLR-2 expression and inhibited TNF-alpha, IL-1 beta, and IL-6 production, while BRP + IPM stimulated these parameters. BPR alone or in combination increased the bactericidal activity similarly to LPS-activated monocytes. Conclusions: Data indicated the potential of BRP as an anti-inflammatory agent increasing the bactericidal activity of monocytes against MRSA. The combination of BRP + IPM exhibited a stimulatory profile that may be potentially useful in treating patients with MRSA infection.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Biosci, Dept Chem & Biol Sci, Campus Botucatu, BR-18618691 Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, BR-14040903 Ribeirao Preto, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Biosci, Dept Chem & Biol Sci, Campus Botucatu, BR-18618691 Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2017/04138-8-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format8-
Idioma: dc.languageen-
Publicador: dc.publisherOxford Univ Press-
Relação: dc.relationJournal Of Pharmacy And Pharmacology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectpropolis-
Palavras-chave: dc.subjectmonocyte-
Palavras-chave: dc.subjectToll-like receptor-
Palavras-chave: dc.subjectcytokine-
Palavras-chave: dc.subjectmethicillin-resistant Staphylococcus aureus-
Título: dc.titleBrazilian red propolis synergistically with imipenem modulates immunological parameters and the bactericidal activity of human monocytes against methicillin-resistant Staphylococcus aureus (MRSA)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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