Additive manufacturing of polylactic acid scaffolds dip-coated with polycaprolactone for bone tissue engineering

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributor11507 W Olympic Blvd-
Autor(es): dc.contributorCalifornia State University-
Autor(es): dc.contributorPontificia Universidad Católica de Valparaíso-
Autor(es): dc.contributorand Technology of Minas Gerais-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorCostabeber, Gabriel-
Autor(es): dc.creatorGuerra, Nayrim Brizuela-
Autor(es): dc.creatorBrasil, Giovana Sant'Ana Pegorin-
Autor(es): dc.creatorSasaki, Josana Carla da Silva-
Autor(es): dc.creatorScontri, Mateus-
Autor(es): dc.creatorBurd, Betina Sayeg-
Autor(es): dc.creatorSu, Yanjin-
Autor(es): dc.creatorTanaka, Jean Lucas-
Autor(es): dc.creatorMandal, Kalpana-
Autor(es): dc.creatorMecwan, Marvin-
Autor(es): dc.creatorFarhadi, Neda-
Autor(es): dc.creatorGómez, Alejandro-
Autor(es): dc.creatorMa, Changyu-
Autor(es): dc.creatorMussagy, Cassamo Ussemane-
Autor(es): dc.creatorSilva, Glaucio Ribeiro-
Autor(es): dc.creatordos Santos, Lindomar Soares-
Autor(es): dc.creatorde Barros, Natan Roberto-
Autor(es): dc.creatorBarbosa, Gustavo Franco-
Autor(es): dc.creatorJucaud, Vadim-
Autor(es): dc.creatorLi, Bingbing-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Data de aceite: dc.date.accessioned2025-08-21T19:04:35Z-
Data de disponibilização: dc.date.available2025-08-21T19:04:35Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mtcomm.2024.109646-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299345-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299345-
Descrição: dc.descriptionBone tissue engineering aims to create scaffolds that support bone regeneration, addressing the needs of approximately 1.71 billion people with bone structure problems worldwide. This study explores the fabrication and characterization of 3D-printed polylactic acid (PLA) scaffolds dip-coated with polycaprolactone (PCL), producing complex geometries with interconnected pores, specifically RoundBar Sphere and RoundBar Cube. The scaffolds were then coated with PCL solutions of 0.5 % and 1 % concentrations, applying up to three layers. Surface topology analysis indicated that PCL coating slightly reduced pore size (1150 µm to 900) while improving coverage and integrity. After coating, Fourier Transform Infrared Spectroscopy (FTIR) confirmed the presence of PCL on scaffold surfaces (characteristic bands at 1726, 1175 and 728 cm−1), whose a better coverage was obtained with more layers and higher concentrations of PCL. Coated scaffolds showed not significant change in compressive strengths (2–12 MPa), remaining suitable for trabecular bone applications. Hemolysis assays of the 3D scaffolds promoted non-hemolytic properties (0 % hemolysis), ensuring their blood compatibility. Metabolic activity (>70 %) and live/dead cell assays in human dermal fibroblasts (HDF) exhibited biocompatibilities for all samples, with coated scaffolds promoting enhanced cell proliferation compared to uncoated ones. Additionally, osteoblast metabolic activity (>90 %) and osteoblasts scratch assay demonstrated coated scaffolds promoted an area reduction of 1.36 and 1.53-fold higher than the control group and uncoated scaffold, respectively. In short, these coated scaffolds are promising candidates for bone tissue engineering and bone repair applications.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionMineral Industry Research Organization-
Descrição: dc.descriptionSão Paulo State University (UNESP) Post-Graduate Program in Biomaterials & Bioprocesses Engineering Biotechnology School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Physics School of Science, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SP-
Descrição: dc.descriptionTerasaki Institute for Biomedical Innovation (TIBI) 11507 W Olympic Blvd-
Descrição: dc.descriptionAutonomy Research Center for STEAHM (ARCS) California State University-
Descrição: dc.descriptionEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de Valparaíso-
Descrição: dc.descriptionFederal Institute of Education Science and Technology of Minas Gerais, s/n São Luiz Gonzaga Street, MG-
Descrição: dc.descriptionFaculty of Philosophy Sciences and Languages of Ribeirão Preto Universidade de São Paulo (USP), 3900 Bandeirantes Avenue, SP-
Descrição: dc.descriptionFederal University of São Carlos (UFSCar) Mechanical Engineering Department Washington Luiz Highway, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Post-Graduate Program in Biomaterials & Bioprocesses Engineering Biotechnology School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Physics School of Science, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SP-
Descrição: dc.descriptionFAPESP: 2011/17411-8-
Descrição: dc.descriptionFAPESP: 2014/17526-8-
Descrição: dc.descriptionFAPESP: 2018/07342-8-
Descrição: dc.descriptionFAPESP: 2021/09207-3-
Descrição: dc.descriptionCNPq: 317203/2021-5-
Descrição: dc.descriptionMineral Industry Research Organization: 80NSSC19M0200-
Idioma: dc.languageen-
Relação: dc.relationMaterials Today Communications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdditive manufacturing-
Palavras-chave: dc.subjectBiodevices-
Palavras-chave: dc.subjectBone tissue engineering-
Palavras-chave: dc.subjectMaterial extrusion-
Palavras-chave: dc.subjectPLA/PCL scaffolds-
Palavras-chave: dc.subjectScratch assays-
Título: dc.titleAdditive manufacturing of polylactic acid scaffolds dip-coated with polycaprolactone for bone tissue engineering-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.