Assessing bone formation on hydrophilic and hydrophobic implant surfaces in a murine model treated with bisphosphonates

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.creatorSánchez-Puetate, Julio Cesar-
Autor(es): dc.creatorSilva, Bruno Luís Graciliano-
Autor(es): dc.creatorPinotti, Felipe Eduardo-
Autor(es): dc.creatorMarcantonio, Camila Chierici-
Autor(es): dc.creatorde Oliveira, Guilherme José Pimentel Lopes-
Autor(es): dc.creatorJunior, Elcio Marcantonio-
Autor(es): dc.creatorMarcantonio, Rosemary Adriana Chierici-
Data de aceite: dc.date.accessioned2025-08-21T21:39:39Z-
Data de disponibilização: dc.date.available2025-08-21T21:39:39Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-023-05480-7-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299329-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299329-
Descrição: dc.descriptionObjective: To evaluate the osseointegration of implants with hydrophobic (HFB) and hydrophilic (HFL) surfaces in a murine model of high-dose bisphosphonates (BPs). Materials and methods: Sixty-four rats were randomly allocated into four groups: control group with HFB implants (CG-HFB), control group with HFL implants (CG-HFL), BP group with HFB implants (BP-HFB), and BP group with HFL implants (BP-HFL). Animals were euthanized after 15 and 45 days (n=8). The dependent variables assessed were the removal torque (biomechanical analysis), the bone volume around the implants (%BV/TV) (microtomographic analysis), the bone-implant contact (%BIC), the bone between the threads (%BBT) (histomorphometric analysis), and the expression of bone metabolism markers (immunohistochemistry analysis). Results: The CG-HFL and BP-HFL groups presented higher removal torque than the CG-HFB and BP-HFB implants. The %BIC of the CG-HFL surfaces was slightly higher than that of the CG-HFB implants. The BP-HFB and BP-HFL groups presented a higher %BIC than that of the CG-HFB and CG-HFL groups (p<0.001). BP therapy also increased the %BBT at both implant surfaces. Higher levels of ALP were observed in the matrix region of bone tissue on the HFL surfaces than on the HFB surfaces. Conclusion: Both surfaces enable osseointegration in rats under BP therapy. Clinical relevance: The study demonstrates that hydrophobic (HFB) and hydrophilic (HFL) implant surfaces can promote osseointegration in rats undergoing bisphosphonate therapy. The HFL surfaces exhibited improved biomechanical performance, higher bone-implant contact, and increased bone volume, suggesting their potential clinical relevance for implant success in individuals on bisphosphonate treatment.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry of Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Periodontology and Implantology School of Dentistry at Uberlândia Federal University of Uberlândia-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry of Araraquara São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBisphosphonates-
Palavras-chave: dc.subjectDental implants-
Palavras-chave: dc.subjectOsseointegration-
Palavras-chave: dc.subjectSurface properties-
Título: dc.titleAssessing bone formation on hydrophilic and hydrophobic implant surfaces in a murine model treated with bisphosphonates-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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