Enhancing hydroxychloroquine detection using carbon paste electrode modified with platinum nanoparticles and MWCNTs

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Grande Dourados (UFGD)-
Autor(es): dc.creatorFeitosa, Maria H. A.-
Autor(es): dc.creatorSantos, Anderson M.-
Autor(es): dc.creatorWong, Ademar-
Autor(es): dc.creatorSotomayor, Maria D. P. T.-
Autor(es): dc.creatorBarros, Willyam R. P.-
Autor(es): dc.creatorLanza, Marcos R. V.-
Autor(es): dc.creatorMoraes, Fernando C.-
Data de aceite: dc.date.accessioned2025-08-21T19:43:52Z-
Data de disponibilização: dc.date.available2025-08-21T19:43:52Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10800-025-02293-2-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299304-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299304-
Descrição: dc.descriptionIn this study, a carbon paste electrode (CPE) modified with multi-walled carbon nanotubes (MWCNTs) and platinum nanoparticles (Pt NPs) was developed for the detection of hydroxychloroquine in environmental and biologic samples. The electrodes defined as MWCNTs/CPE and Pt NPs-MWCNTs/CPE, were subjected to characterization analyses, where their structural and morphological properties were investigated. The electrochemical measurements were carried out using cyclic and square wave voltammetry techniques. Under optimal conditions, the proposed sensor displayed a linear concentration range of 0.099–7.1 µmol L‒1 (n = 3) in 0.10 mol L−1 phosphate buffer solution at pH 6.0, with detection and quantification limits of 28 nmol L‒1 and 93 nmol L‒1, respectively. The selectivity of the proposed sensor toward hydroxychloroquine detection was verified in the presence of potential interferents, such as uric acid, glucose, urea, ascorbic acid, albumin, metals, and humic acid. For the analysis of its applicability, the sensor was successfully applied for hydroxychloroquine detection in biologic and environmental samples, where the results obtained were comparable to those obtained under spectrophotometry (reference method), thus confirming the feasibility of the method. The findings of this study show that the proposed sensor exhibits exceptional performance and is suitable for use in the detection of pharmaceuticals in different real matrices.-
Descrição: dc.descriptionDepartment of Chemistry Federal University of São Carlos (UFSCar), SP-
Descrição: dc.descriptionSão Carlos Institute of Chemistry University of São Paulo (USP), SP-
Descrição: dc.descriptionInstitute of Chemistry State University of São Paulo (UNESP), SP-
Descrição: dc.descriptionFederal University of Grande Dourados (UFGD), MS-
Descrição: dc.descriptionInstitute of Chemistry State University of São Paulo (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Electrochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCarbon nanotube-
Palavras-chave: dc.subjectCarbon paste electrode-
Palavras-chave: dc.subjectHydroxychloroquine-
Palavras-chave: dc.subjectModified electrode-
Palavras-chave: dc.subjectPlatinum nanoparticles-
Título: dc.titleEnhancing hydroxychloroquine detection using carbon paste electrode modified with platinum nanoparticles and MWCNTs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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