Eight sessions of transcranial electrical stimulation for postural response in people with Parkinson's disease: A randomized trial

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorNorthumbria University-
Autor(es): dc.creatorBeretta, Victor Spiandor-
Autor(es): dc.creatorOrcioli-Silva, Diego-
Autor(es): dc.creatorZampier, Vinicius Cavassano-
Autor(es): dc.creatorMoraca, Gabriel Antonio Gazziero-
Autor(es): dc.creatorPereira, Marcelo Pinto-
Autor(es): dc.creatorGobbi, Lilian Teresa Bucken-
Autor(es): dc.creatorVitório, Rodrigo-
Data de aceite: dc.date.accessioned2025-08-21T20:50:42Z-
Data de disponibilização: dc.date.available2025-08-21T20:50:42Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.gaitpost.2024.08.076-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299302-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299302-
Descrição: dc.descriptionBackground: Impairments in postural responses to perturbation are common in people with Parkinson's disease (PwPD) and lack effective treatment. We recently showed that a single session of transcranial direct current stimulation (tDCS) promotes acute improvement of postural response to perturbation in PwPD. However, the effects of multiple tDCS sessions remain unclear. Research question: What is the efficacy of eight sessions of anodal tDCS on postural responses to external perturbation in PwPD? Methods: Twenty-two PwPD participated in this randomized, double-blind, parallel-arm, and sham-controlled study. Participants were randomly distributed into active (a-tDCS; n=11) or sham stimulation (s-tDCS; n=11). Eight tDCS sessions were applied over the primary motor cortex (M1), with the a-tDCS group receiving 2 mA for 20 minutes. Postural responses to external perturbations were assessed before, 48 hours after, and one month after (follow-up) the completion of tDCS sessions. Primary outcome measures included the onset latency of medial gastrocnemius (MG) muscle and range of center of pressure. Secondary outcomes included electromyography and CoP parameters, and prefrontal cortex (PFC) activity. Results: ANOVA revealed a trend for Group*Moment interaction for MG onset latency (p=0.058). a-tDCS tended to have shorter MG onset latency at post-test (p=0.040; SRM = −0.63) compared to pre-test. For the secondary outcomes, only a-tDCS decreased the time taken to recover balance after the perturbation at post-test and follow-up compared to pre-test (both p<0.001; SRM=-1.42 and −1.53, respectively). Also, only a-tDCS demonstrated lower PFC activity at post-test compared to pre-test (p=0.017; SRM = −0.82) and follow-up (p=0.001). Significance: Eight sessions of tDCS over M1 improved postural response to perturbation in PwPD. Some benefits lasted for at least a month. Neuromuscular and behavioral changes observed after the intervention were accompanied by decreased PFC activity (executive-attentional control), suggesting that tDCS applied over M1 can improve movement automaticity.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Biosciences Graduate Program in Movement Sciences Posture and Gait Studies Laboratory (LEPLO)-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Technology and Sciences Physical Education Department-
Descrição: dc.descriptionUniversity of Campinas (UNICAMP) School of Applied Sciences (FCA) Laboratory of Applied Sport Physiology (LAFAE)-
Descrição: dc.descriptionDepartment of Sport Exercise and Rehabilitation Northumbria University-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Biosciences Graduate Program in Movement Sciences Posture and Gait Studies Laboratory (LEPLO)-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Technology and Sciences Physical Education Department-
Descrição: dc.descriptionCNPq: #142057/2017-7-
Descrição: dc.descriptionFAPESP: #2014/22308-0-
Descrição: dc.descriptionFAPESP: #2018/07385-9, #2016/21499-1-
Descrição: dc.descriptionCNPq: #309045/2017-7-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format1-7-
Idioma: dc.languageen-
Relação: dc.relationGait and Posture-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBrain stimulation-
Palavras-chave: dc.subjectMovement Disorders-
Palavras-chave: dc.subjectNeurodegenerative disease-
Palavras-chave: dc.subjectPostural balance-
Palavras-chave: dc.subjectTDCS-
Título: dc.titleEight sessions of transcranial electrical stimulation for postural response in people with Parkinson's disease: A randomized trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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