Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSchool of Medicine of São José do Rio Preto (FAMERP)-
Autor(es): dc.creatorGusson-Zanetoni, Juliana Prado-
Autor(es): dc.creatorCardoso, Luana Pereira-
Autor(es): dc.creatorde Sousa, Stefanie Oliveira-
Autor(es): dc.creatorde Melo Moreira Silva, Laura Luciana-
Autor(es): dc.creatorde Oliveira Martinho, Júlia-
Autor(es): dc.creatorHenrique, Tiago-
Autor(es): dc.creatorTajara, Eloiza Helena-
Autor(es): dc.creatorOliani, Sonia Maria-
Autor(es): dc.creatorRodrigues-Lisoni, Flávia Cristina-
Data de aceite: dc.date.accessioned2025-08-21T21:39:53Z-
Data de disponibilização: dc.date.available2025-08-21T21:39:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms25115762-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299296-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299296-
Descrição: dc.descriptionPiperine, an active plant alkaloid from black pepper (Piper nigrum), has several pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory effects, which involve inhibiting molecular events associated with various stages of cancer development. The aim of this study was to investigate the molecular mechanisms of action of piperine in relation to its potential anticancer effect on head and neck cancer cells. Parameters related to neoplastic potential and cytokine, protein and gene expression were investigated in head and neck cancer cell lines (HEp-2 and SCC-25) treated with piperine. The results of the tests indicated that piperine modified morphology and inhibited viability and the formation of cell colonies. Piperine promoted genotoxicity by triggering apoptosis and cell cycle arrest in the G2/M and S phases. A decrease in cell migration was also observed, and there was decreased expression of MMP2/9 genes. Piperine also reduced the expression of inflammatory molecules (PTGS2 and PTGER4), regulated the secretion of cytokines (IFN-γ and IL-8) and modulated the expression of ERK and p38. These results suggest that piperine exerts anticancer effects on tumor cells by regulating signaling pathways associated with head and neck cancer.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Science (IBILCE) São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Molecular Biology School of Medicine of São José do Rio Preto (FAMERP)-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Science (IBILCE) São Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: 141072/2020-2-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjectherbal medicine-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectMAPK-
Palavras-chave: dc.subjectMMPs-
Palavras-chave: dc.subjectPTGS2-
Título: dc.titleMolecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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