Biofilm modulation and demineralization reduction after treatment with a new toothpaste formulation containing fluoride, casein phosphopeptide-amorphous calcium phosphate, and sodium trimetaphosphate: In situ study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorTU Dresden-
Autor(es): dc.contributorAnn and Robert Lurie Children's Hospital-
Autor(es): dc.creatorGonçalves, Francyenne Maira Castro-
Autor(es): dc.creatorde Almeida, Eduarda Martins Fontes Cantarella-
Autor(es): dc.creatorHannig, Christian-
Autor(es): dc.creatorQuinteiro, Julia Paião-
Autor(es): dc.creatorDelbem, Alberto Carlos Botazzo-
Autor(es): dc.creatorCannon, Mark Lloyd-
Autor(es): dc.creatorDanelon, Marcelle-
Data de aceite: dc.date.accessioned2025-08-21T17:04:27Z-
Data de disponibilização: dc.date.available2025-08-21T17:04:27Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.dental.2024.09.018-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299255-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299255-
Descrição: dc.descriptionObjective: This in situ study aimed to evaluate a new toothpaste formulation containing fluoride (F), casein phosphopeptide amorphous calcium phosphate (CPP-ACP) and sodium trimetaphosphate (TMP) on the process of dental demineralization and biofilm composition. Methods: This crossover double-blind study consisted of five phases, in which 10 volunteers wore intraoral appliances containing four bovine enamel specimens. The cariogenic challenge was performed using 30 % sucrose solution. Blocks were treated 3 ×/day with the following toothpastes: 1) Placebo (No F-TMP-CPP-ACP), 2) 1100 ppm F (1100F), 3) 1100F + 3 %TMP (1100F-TMP), 4) 1100F + 10 %CPP-ACP (1100F-CPP-ACP) and 5) 1100F-CPP-ACP-TMP. After 7 days, the percentage loss of surface hardness (%SH), integrated loss of subsurface hardness (ΔKHN), F, calcium (Ca) and phosphorus (P) concentration in the enamel was determined. The concentration of F, Ca, P and insoluble extracellular polysaccharide (EPS) in the biofilm were analyzed. Results: The addition of CPP-ACP-TMP to 1100F reduced %SH by 42 % and 39 % when compared to the 1100F and 1100F-CPP-ACP (p < 0.001); in addition, to a reduction in lesion body (ΔKHN) by 36 % for the same treatments. The treatment with 1100F-CPP-ACP-TMP led to a significant increase in the concentration of F, P and Ca in the enamel and biofilm, and reduced the concentration of EPS (p < 0.001). Significance: Toothpaste formulation containing 1100F-CPP-ACP-TMP prevented the reduction of enamel hardness and significantly influenced the ionic biochemical composition and insoluble extracellular polysaccharide (EPS) in biofilm formed in situ. These results are promising and provide valuable insights for the design of further clinical trials.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Pediatric Dentistry and Public Health, Rua José Bonifácio 1193, SP-
Descrição: dc.descriptionDepartment of Pediatric Clinics School of Dentistry of Ribeirão Preto São Paulo University, Avenida do Cafe, s/no, SP-
Descrição: dc.descriptionPolyclinic of Operative Dentistry Periodontology and Pediatric Dentistry Faculty of Medicine Carl Gustav Carus TU Dresden, Fetscherstraße 74-
Descrição: dc.descriptionNorthwestern University Feinberg School of Medicine Ann and Robert Lurie Children's Hospital-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Pediatric Dentistry and Public Health, Rua José Bonifácio 1193, SP-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2021/06408-8-
Formato: dc.format2077-2084-
Idioma: dc.languageen-
Relação: dc.relationDental Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiofilm-
Palavras-chave: dc.subjectDemineralization-
Palavras-chave: dc.subjectDental enamel-
Palavras-chave: dc.subjectPhosphates-
Título: dc.titleBiofilm modulation and demineralization reduction after treatment with a new toothpaste formulation containing fluoride, casein phosphopeptide-amorphous calcium phosphate, and sodium trimetaphosphate: In situ study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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