Menadione and protocatechuic acid: A drug combination with antitumor effects in murine osteosarcoma cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorSanford Children's Health Research Center. Sanford Burnham Prebys Medical Discovery Institute-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorInacio, Kelly Karina-
Autor(es): dc.creatorPessoa, Adriano de Souza-
Autor(es): dc.creatorTokuhara, Cintia Kazuko-
Autor(es): dc.creatorPagnan, Ana Lígia-
Autor(es): dc.creatorSanches, Mariana Liessa Rovis-
Autor(es): dc.creatorFakhoury, Vanessa Svizzero-
Autor(es): dc.creatorOliveira, Gabriela Silva Neubern de-
Autor(es): dc.creatorOliveira, Flavia Amadeu de-
Autor(es): dc.creatorXimenes, Valdecir Farias-
Autor(es): dc.creatorOliveira, Rodrigo Cardoso de-
Data de aceite: dc.date.accessioned2025-08-21T22:19:32Z-
Data de disponibilização: dc.date.available2025-08-21T22:19:32Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.abb.2023.109840-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299148-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299148-
Descrição: dc.descriptionOsteosarcoma (OS) is a primary malignant bone tumor that has an abnormal expression of oncogenesis and tumor suppressors and causes dysregulation of various signaling pathways. Thus, novel therapeutic strategies for OS are needed to overcome the resistance of traditional treatments. This study evaluated the cytotoxic and anticancer effects of the association between menadione (MEN) and protocatechuic acid (PCA) in murine OS cells (UMR-106). The concentrations were 3.12 μM of isolated MEN, 500 μM of isolated PCA, and their associations. We performed cell viability assays, morphology modification analysis, cell migration by the wound-healing method, apoptosis by flow cytometry, reactive oxygen species (ROS) production, gene expression of NOX by RT-qPCR, and degradation of MMP-2 and 9 by zymography. Our results showed that the association of MEN+PCA was more effective in OS cells than the compounds alone. The association decreased cell viability, delayed cell migration, and decreased the expression of NOX-2 and ROS. In addition, the MEN+PCA association induced a slight increase in the apoptotic process. In summary, the association can enhance the compound's antitumor effects and establish a higher selectivity for tumor cells, possibly caused by significant mitochondrial damage and antioxidant properties.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo-
Descrição: dc.descriptionSanford Children's Health Research Center. Sanford Burnham Prebys Medical Discovery Institute, La Jolla-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences UNESP São Paulo State University, Bauru-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences UNESP São Paulo State University, Bauru-
Descrição: dc.descriptionFAPESP: #2016/08890-3-
Descrição: dc.descriptionFAPESP: #2021/13697-6-
Descrição: dc.descriptionCNPq: #308897/2021-8-
Idioma: dc.languageen-
Relação: dc.relationArchives of Biochemistry and Biophysics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMEN + PCA association-
Palavras-chave: dc.subjectMenadione-
Palavras-chave: dc.subjectOsteosarcoma-
Palavras-chave: dc.subjectProtocatechuic acid-
Palavras-chave: dc.subjectUMR-106-
Título: dc.titleMenadione and protocatechuic acid: A drug combination with antitumor effects in murine osteosarcoma cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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