Absence of melatonin during development impairs craniofacial and dental onset in rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorHermínio Ometto Foundation - FHO-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorGraduate Program of Orthodontics Hermínio Ometto Foundation - FHO-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCalsa, Bruno-
Autor(es): dc.creatorde Camargo, Ludmilla Scodeler-
Autor(es): dc.creatorBortolança, Tainá Jaqueline-
Autor(es): dc.creatorde Oliveira, Camila Andrea-
Autor(es): dc.creatorCatisti, Rosana-
Autor(es): dc.creatordo Amaral, Fernanda Gaspar-
Autor(es): dc.creatorSantamaria-Jr, Milton-
Data de aceite: dc.date.accessioned2025-08-21T15:38:36Z-
Data de disponibilização: dc.date.available2025-08-21T15:38:36Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-023-05155-3-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299146-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299146-
Descrição: dc.descriptionObjective: Herein, we evaluated pinealectomy-induced melatonin absence to determine its effects on craniofacial and dental development in the offspring. Design: Female Wistar rats in three groups, i.e., intact pregnant rats, pinealectomized pregnant rats (PINX), and pinealectomized pregnant rats subjected to oral melatonin replacement therapy, were crossed 30 days after surgery. The heads of 7-day-old pups were harvested for cephalometric and histological analyses, and maxillae and incisors were collected for mRNA expression analysis. Results: The PINX pups exhibited a reduction in neurocranial and facial parameters such as a decrease in alveolar bone area, incisor size and proliferation, and an increase in odontoblasts and the dentin layer. Based on incisor mRNA expression analysis, we found that Dmp1 expression was upregulated, whereas Col1a1 expression was downregulated. Maxillary mRNA expression revealed that Rankl expression was upregulated, whereas that of Opn and Osx was downregulated. Conclusion: Our results demonstrated that the absence of maternal melatonin during early life could affect dental and maxillary development in offspring, as well as delay odontogenesis and osteogenesis in maxillary tissues. Clinical relevance: Our findings suggest that disruptions or a lack of melatonin during pregnancy may cause changes in craniofacial and dental development, at least in animal experiments; however, in humans, these feedings are still poorly understood, and thus careful evaluations of melatonin levels in humans need to be investigated in craniofacial alterations.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionGraduate Program of Biomedical Sciences Hermínio Ometto Foundation - FHO, SP-
Descrição: dc.descriptionFetal Programming and Hydroelectrolyte Metabolism Laboratory Department of Internal Medicine Faculty of Medical Sciences at State University of Campinas - UNICAMP, SP-
Descrição: dc.descriptionPineal Neurobiology Laboratory Department of Physiology Federal University of São Paulo - UNIFESP, SP-
Descrição: dc.descriptionGraduate Program of Orthodontics Hermínio Ometto Foundation - FHO, SP-
Descrição: dc.descriptionDepartment of Physiology and Biophysics Institute of Biomedical Sciences University of São Paulo - USP, SP-
Descrição: dc.descriptionDepartment of Social and Pediatric Dentistry Institute of Science and Technology - College of Dentistry UNESP - São Paulo State University, Av. Eng. Francisco José Longo 777, SP-
Descrição: dc.descriptionDepartment of Social and Pediatric Dentistry Institute of Science and Technology - College of Dentistry UNESP - São Paulo State University, Av. Eng. Francisco José Longo 777, SP-
Descrição: dc.descriptionFAPESP: FAPESP - 16/23237-4-
Descrição: dc.descriptionCNPq: PIBIC/CNPq - 143262/2021-1-
Formato: dc.format5353-5365-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFetal programming-
Palavras-chave: dc.subjectMelatonin and RANKL/OPG-
Palavras-chave: dc.subjectOdontogenesis-
Palavras-chave: dc.subjectOsteogenesis-
Título: dc.titleAbsence of melatonin during development impairs craniofacial and dental onset in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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