Periodontal inflammatory and microbial profiles in healthy young African Americans and Caucasians

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Autor(es): dc.contributorUniversity of Kentucky-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Texas Medical Branch at Galveston-
Autor(es): dc.creatorSabbagh, Samer-
Autor(es): dc.creatorAdatorwovor, Reuben-
Autor(es): dc.creatorKirakodu, Sreenatha-
Autor(es): dc.creatorRojas-Ramirez, Marcia V.-
Autor(es): dc.creatorAl-Sabbagh, Mohanad-
Autor(es): dc.creatorDawson, Dolphus-
Autor(es): dc.creatorFernandes, Jussara Gonçalves-
Autor(es): dc.creatorMiguel, Manuela Maria Viana-
Autor(es): dc.creatorVillasante-Tezanos, Alejandro-
Autor(es): dc.creatorShaddox, Luciana-
Data de aceite: dc.date.accessioned2025-08-21T17:39:48Z-
Data de disponibilização: dc.date.available2025-08-21T17:39:48Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jcpe.13989-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299114-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299114-
Descrição: dc.descriptionAim: This study aimed to compare microbial and inflammatory profiles in periodontally/systemically healthy African American (AA) and Caucasian (C) individuals. Materials and Methods: Thirty-seven C and 46 AA aged from 5 to 25 years were evaluated regarding periodontal disease, caries, microbial subgingival profile via 16-s sequencing, as well as salivary and gingival crevicular fluid (GCF) inflammatory profile via multiplex assay. Results: Greater probing depth percentage was detected in AA (p =.0075), while a higher percentage of caries index (p =.0069) and decayed, missing, filled teeth (DMFT) index (p =.0089) was observed in C, after adjusting for number of teeth, sex and age. Salivary levels of IL-6, IL-8 and TNFα were higher for C, whereas GCF levels of eotaxin, IL-12p40, IL-12p70, IL-2 and MIP-1α were higher in AA (p <.05). Different microbial profiles were observed between the races (p =.02). AA presented higher abundance of periodontopathogens (such as Tanerella forsythia, Treponema denticola, Filifactor alocis, among others), and C presented more caries-associated bacteria (such as Streptococcus mutans and Prevotella species). Bacillaceae and Lactobacillus species were associated with higher DMFT index, whereas Fusobacterium and Tanerella species with periodontal disease parameters. Conclusions: A different inflammatory and bacterial profile was observed between healthy AA and C, which may predispose these races to higher susceptibility to specific oral diseases.-
Descrição: dc.descriptionNational Institute of Dental and Craniofacial Research-
Descrição: dc.descriptionDepartment of Oral Health Practice Periodontology Division College of Dentistry University of Kentucky-
Descrição: dc.descriptionDepartment of Biostatistics College of Public Health University of Kentucky-
Descrição: dc.descriptionCenter for Oral Health Research College of Dentistry University of Kentucky-
Descrição: dc.descriptionDepartment of Oral Health Practice Division of Oral Medicine Oral Diagnosis and Oral Radiology University of Kentucky-
Descrição: dc.descriptionDivision of Periodontics Institute of Science and Technology – São Paulo State University (Unesp) São José dos Campos-
Descrição: dc.descriptionDepartment of Preventive Medicine and Population Health University of Texas Medical Branch at Galveston-
Descrição: dc.descriptionDivision of Periodontics Institute of Science and Technology – São Paulo State University (Unesp) São José dos Campos-
Descrição: dc.descriptionNational Institute of Dental and Craniofacial Research: R01DE019456-
Formato: dc.format895-904-
Idioma: dc.languageen-
Relação: dc.relationJournal of Clinical Periodontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadolescents-
Palavras-chave: dc.subjectAfrican Americans-
Palavras-chave: dc.subjectbiomarkers-
Palavras-chave: dc.subjectCaucasians-
Palavras-chave: dc.subjectmicrobiota/microbiome-
Título: dc.titlePeriodontal inflammatory and microbial profiles in healthy young African Americans and Caucasians-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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