An Innovative Biomaterial: 45S5 Bioactive Glass Functionalized with PTH 1–34 In Vivo Bone Repair

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorRua Gomes Carneiro-
Autor(es): dc.creatorde Araújo, Juliani Caroline Ribeiro-
Autor(es): dc.creatorSilva, Leonardo Alvares Sobral-
Autor(es): dc.creatorde Oliveira, Elisa Freire Sant’Anna-
Autor(es): dc.creatorVieira, Marília Nanni-
Autor(es): dc.creatorFilho, Paulo Noronha Lisboa-
Autor(es): dc.creatorCampos, Tiago Moreira Bastos-
Autor(es): dc.creatorOkamoto, Roberta-
Autor(es): dc.creatorde Vasconcellos, Luana Marotta Reis-
Data de aceite: dc.date.accessioned2025-08-21T19:18:59Z-
Data de disponibilização: dc.date.available2025-08-21T19:18:59Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12668-025-01819-4-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299105-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299105-
Descrição: dc.descriptionDeveloping functional biomaterials with optimized properties is a major challenge in tissue engineering. Materials such as bioactive glasses have been widely studied due to their potential for bone regeneration. In the present study, we aimed to develop 45S5 bioactive glass functionalized with 10% PTH 1–34 and evaluate the effects of the biomaterial on bone regeneration and the healing of critical bone defects in female rats. The preparation of the biomaterial involved the production of 45S5 bioactive glass using the sol–gel technique, followed by melting and quenching. To this end, thirty female Wistar rats were randomly assigned to two groups: one with 5-mm critical bone defects in the calvaria and another with 3-mm defects in the tibiae. The defects were filled with either bioactive glass (BG) or bioactive glass functionalized with 10% teriparatide (BGTer). The animals were euthanized at 2- and 6-weeks post-operation, and their defects were analyzed using histological, histomorphometry, immunohistochemical, and biomechanical methods (via a three-point bending test). Data were statistically assessed using ANOVA and Tukey’s post hoc test, with a significance level of 5%. The results showed that PTH 1–34, associated with the bioactive glass, was successfully incorporated and had a positive effect on bone repair in the studied model. We concluded that the biomaterial minimized the potential side effects and complications associated with systemic administration by transforming PTH 1–34 into a localized delivery system, representing a significant innovation of medical bioengineering.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionInstitute of Science and Technology São Paulo State University (UNESP), Av. Engenheiro Francisco José Longo777, Jd São Dimas, SP-
Descrição: dc.descriptionDepartment of Physics São Paulo State University School of Sciences, SP-
Descrição: dc.descriptionFederal University of Pelotas Pelotas Rua Gomes Carneiro, 1 – Centro – CEP 96010-610 – Pelotas, RS – Brasil-
Descrição: dc.descriptionDepartment of Surgery and Integrated Clinic São Paulo State University Araçatuba Dental School, SP-
Descrição: dc.descriptionInstitute of Science and Technology São Paulo State University (UNESP), Av. Engenheiro Francisco José Longo777, Jd São Dimas, SP-
Descrição: dc.descriptionDepartment of Physics São Paulo State University School of Sciences, SP-
Descrição: dc.descriptionDepartment of Surgery and Integrated Clinic São Paulo State University Araçatuba Dental School, SP-
Descrição: dc.descriptionFAPESP: 2019/04185-1-
Descrição: dc.descriptionCAPES: 88887.636794/2021- 00-
Idioma: dc.languageen-
Relação: dc.relationBioNanoScience-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiocompatible Materials-
Palavras-chave: dc.subjectBone Development-
Palavras-chave: dc.subjectBone Regeneration-
Palavras-chave: dc.subjectTeripatide-
Palavras-chave: dc.subjectTissue Engineering-
Título: dc.titleAn Innovative Biomaterial: 45S5 Bioactive Glass Functionalized with PTH 1–34 In Vivo Bone Repair-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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