Quantification of florfenicol and its metabolites in fillets of Nile tilapia: Synthesis of metabolites and validation of an on-line solid-phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry method

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorComparative Microbiome Analysis Research Unit-
Autor(es): dc.creatorPaula Rocha de Queiroga, Anna-
Autor(es): dc.creatorFreitas Pereira de Souza, Gabriela-
Autor(es): dc.creatorMateus Assane, Inácio-
Autor(es): dc.creatorMessias, Thiago-
Autor(es): dc.creatorPilarski, Fabiana-
Autor(es): dc.creatorSchloter, Michael-
Autor(es): dc.creatorGonçalves Salles, Airton-
Autor(es): dc.creatorRath, Susanne-
Data de aceite: dc.date.accessioned2025-08-21T18:27:45Z-
Data de disponibilização: dc.date.available2025-08-21T18:27:45Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jchromb.2024.124282-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299061-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299061-
Descrição: dc.descriptionThis study concerns the synthesis of the florfenicol (FF) metabolites florfenicol amine (FFA), florfenicol alcohol (FFOH), and monochloroflorfenicol (FFCl), for their subsequent use as reference standards in On-line solid-phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry (SPE-UHPLC-MS/MS) analysis. The metabolites were characterized using 1H and 13C NMR, as well as HRMS, and their purities were confirmed by quantitative NMR to ensure analytical reliability. Validation of the developed analytical method showed that it presented acceptable performance, with linearity >0.99 for all the target analytes, accuracies within ±10 % of nominal concentrations, and intra- and inter-day precisions within 15 %. Application of this method to fillets from fish that had been treated with florfenicol (dose of 10 mg/kg bw daily) demonstrated its effectiveness in consistently detecting FF and its metabolites throughout the treatment. The results emphasized the utility of the method for enhancing pharmacokinetic and residue depletion research. The ability to precisely monitor the drug and its metabolites in treated fish provides important insights into florfenicol metabolism, laying the groundwork for further comprehensive profiling studies of metabolites in fish tissue.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Analytical Chemistry Institute of Chemistry University of Campinas, Rua Monteiro Lobato, 270, Cidade Universitária, SP-
Descrição: dc.descriptionDepartment of Organic Chemistry Institute of Chemistry University of Campinas, Rua Monteiro Lobato, 270, Cidade Universitária, SP-
Descrição: dc.descriptionLaboratory of Microbiology and Parasitology of Aquatic Organisms São Paulo State University (UNESP), Aquaculture Center of UNESP, SP-
Descrição: dc.descriptionGraduate Program in Agricultural and Livestock Microbiology São Paulo State University (UNESP) School of Agricultural and Veterinary Sciences, SP-
Descrição: dc.descriptionHelmholtz Zentrum München Comparative Microbiome Analysis Research Unit, Ingolstädter Landstraße 1-
Descrição: dc.descriptionLaboratory of Microbiology and Parasitology of Aquatic Organisms São Paulo State University (UNESP), Aquaculture Center of UNESP, SP-
Descrição: dc.descriptionGraduate Program in Agricultural and Livestock Microbiology São Paulo State University (UNESP) School of Agricultural and Veterinary Sciences, SP-
Descrição: dc.descriptionCNPq: #304584/2021-5-
Idioma: dc.languageen-
Relação: dc.relationJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntimicrobial residues-
Palavras-chave: dc.subjectFish tissue analysis-
Palavras-chave: dc.subjectFlorfenicol-
Palavras-chave: dc.subjectMetabolites synthesis-
Palavras-chave: dc.subjectOn-line solid-phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry-
Palavras-chave: dc.subjectQuEChERS-
Título: dc.titleQuantification of florfenicol and its metabolites in fillets of Nile tilapia: Synthesis of metabolites and validation of an on-line solid-phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry method-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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