Functional modularity and mechanical stress shape plastic responses during fish development

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorOklahoma State University-
Autor(es): dc.creatorLofeu, Leandro-
Autor(es): dc.creatorMontefeltro, Felipe-
Autor(es): dc.creatorSimon, Monique Nouailhetas-
Autor(es): dc.creatorKohlsdorf, Tiana-
Data de aceite: dc.date.accessioned2025-08-21T15:29:17Z-
Data de disponibilização: dc.date.available2025-08-21T15:29:17Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/evolut/qpae086-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299047-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299047-
Descrição: dc.descriptionThe adaptive potential of plastic phenotypes relies on combined developmental responses. We investigated how manipulation of developmental conditions related to foraging mode in the fish Megaleporinus macrocephalus induces plastic responses at different levels: (a) functional modularity of skull bones, (b) biomechanical properties of the chondrocranium using finite element models, (c) bmp4 expression levels, used as a proxy for molecular pathways involved in bone responses to mechanical load. We identified new modules in experimental groups, suggesting increased integration in specific head bone elements associated with the development of subterminal and upturned mouths, which are major features of Megaleporinus plastic morphotypes released in the lab. Plastic responses in head shape involved differences in the magnitude of mechanical stress, which seem restricted to certain chondrocranium regions. Three bones represent a mechanical unitrelated to changes in mouth position induced by foraging mode, suggesting that functional modularity might be enhanced by the way specific regions respond to mechanical load. Differences in bmp4 expression levels between plastic morphotypes indicate associations between molecular signaling pathways and biomechanical responses to load. Our results offer a multilevel perspective of epigenetic factors involved in plastic responses, expanding our knowledge about mechanisms of developmental plasticity that originate novel complex phenotypes.-
Descrição: dc.descriptionLaboratório de Evolução e Biologia Integrativa Departamento de Biologia - FFCLRP University of São Paulo, Ribeirão Preto-
Descrição: dc.descriptionDepartamento de Biologia e Zootecnia Universidade Estadual Paulista-UNESP, Ilha Solteira-
Descrição: dc.descriptionDepartment of Integrative Biology Oklahoma State University-
Descrição: dc.descriptionDepartamento de Biologia e Zootecnia Universidade Estadual Paulista-UNESP, Ilha Solteira-
Formato: dc.format1568-1582-
Idioma: dc.languageen-
Relação: dc.relationEvolution-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdevelopmental plasticity-
Palavras-chave: dc.subjectfinite element analysis-
Palavras-chave: dc.subjectmodularity-
Palavras-chave: dc.subjectskull-
Título: dc.titleFunctional modularity and mechanical stress shape plastic responses during fish development-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.