Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUT Health San Antonio-
Autor(es): dc.contributorUniversity of the Incarnate Word-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorComenius University-
Autor(es): dc.contributorHospital Universitario de Canarias-
Autor(es): dc.creatorReiter, Russel J.-
Autor(es): dc.creatorSharma, Ramaswamy-
Autor(es): dc.creatorChuffa, Luiz Gustavo de Almeida-
Autor(es): dc.creatorSimko, Fedor-
Autor(es): dc.creatorDominguez-Rodriguez, Alberto-
Data de aceite: dc.date.accessioned2025-08-21T19:08:42Z-
Data de disponibilização: dc.date.available2025-08-21T19:08:42Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/life14010088-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298966-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298966-
Descrição: dc.descriptionCardiovascular disease is the cause of physical infirmity and thousands of deaths annually. Typically, during heart failure, cardiomyocyte mitochondria falter in terms of energy production and metabolic processing. Additionally, inflammation and the accumulation of non-contractile fibrous tissue contribute to cardiac malfunction. Melatonin, an endogenously produced molecule, experimentally reduces the initiation and progression of atherosclerotic lesions, which are often the basis of coronary artery disease. The current review critically analyzes published data related to the experimental use of melatonin to forestall coronary artery pathologies. Collectively, these studies document melatonin’s anti-atherosclerotic actions in reducing LDL oxidation and triglyceride levels, lowering endothelial malfunction, limiting adhesion molecule formation, preventing macrophage polarization to the M1 pro-inflammatory phenotype, changing cellular metabolism, scavenging destructive reactive oxygen species, preventing the proliferation and invasion of arterial smooth muscle cells into the lesioned area, restricting the ingrowth of blood vessels from the vasa vasorum, and solidifying the plaque cap to reduce the chance of its rupture. Diabetic hyperglycemia, which aggravates atherosclerotic plaque formation, is also inhibited by melatonin supplementation in experimental animals. The potential value of non-toxic melatonin as a possible inhibitor of cardiac pathology in humans should be seriously considered by performing clinical trials using this multifunctional molecule.-
Descrição: dc.descriptionDepartment of Cell Systems and Anatomy Long School of Medicine UT Health San Antonio-
Descrição: dc.descriptionApplied Biomedical Sciences School of Osteopathic Medicine University of the Incarnate Word-
Descrição: dc.descriptionDepartment of Structural and Functional Biology-IBB/UNESP Institute of Biosciences of Botucatu Universidade Estadual Paulista, São Paulo-
Descrição: dc.descriptionInstitute of Pathophysiology Faculty of Medicine Comenius University-
Descrição: dc.descriptionServicio de Cardiología Hospital Universitario de Canarias-
Descrição: dc.descriptionDepartment of Structural and Functional Biology-IBB/UNESP Institute of Biosciences of Botucatu Universidade Estadual Paulista, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationLife-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectarterial plaque-
Palavras-chave: dc.subjectarterial plaque metabolism-
Palavras-chave: dc.subjectcardiac fibrosis-
Palavras-chave: dc.subjectcardiovascular disease-
Palavras-chave: dc.subjectcoronary artery-
Palavras-chave: dc.subjectdiabetic cardiomyopathy-
Palavras-chave: dc.subjecthypertensive heart-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectmelatonin actions-
Título: dc.titleMitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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