Inhibitors and activators for myotoxic phospholipase A2-like toxins from snake venoms – A structural overview

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad de Costa Rica-
Autor(es): dc.creatorSalvador, Guilherme H.M.-
Autor(es): dc.creatorCardoso, Fábio F.-
Autor(es): dc.creatorLomonte, Bruno-
Autor(es): dc.creatorFontes, Marcos R.M.-
Data de aceite: dc.date.accessioned2025-08-21T18:52:29Z-
Data de disponibilização: dc.date.available2025-08-21T18:52:29Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.biochi.2024.07.016-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298960-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298960-
Descrição: dc.descriptionSnakebite envenomations result in acute and chronic physical and psychological health effects on their victims, leading to a substantial socio-economic burden in tropical and subtropical countries. Local necrosis is one of the serious effects caused by envenomation, primarily induced by snake venoms from the Viperidae family through the direct action of components collectively denominated as myotoxins, including the phopholipase A2-like (PLA2-like) toxins. Considering the limitations of antivenoms in preventing the rapid development of local tissue damage caused by envenomation, the use of small molecule therapeutics has been suggested as potential first-aid treatments or as adjuvants to antivenom therapy. In this review, we provide an overview of the structural interactions of molecules exhibiting inhibitory activity toward PLA2-like toxins. Additionally, we discuss the implications for the myotoxic mechanism of PLA2-like toxins and the molecules involved in their activation, highlighting key differences between activators and inhibitors. Finally, we integrate all these results to propose a classification of inhibitors into three different classes and five sub-classes. Taking into account the structural and affinity information, we compare the different inhibitors/ligands to gain a deeper understanding of the structural basis for the effective inhibition of PLA2-like toxins. By offering these insights, we aim to contribute to the search for new and efficient inhibitor molecules to complement and improve current therapy by conventional antivenoms.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartamento de Biofísica e Farmacologia Instituto de Biociências Universidade Estadual Paulista (UNESP), Botucatu-SP-
Descrição: dc.descriptionInstituto Clodomiro Picado Facultad de Microbiología Universidad de Costa Rica-
Descrição: dc.descriptionInstituto de Estudos Avançados do Mar (IEAMar) Universidade Estadual Paulista (UNESP), São Vicente-SP-
Descrição: dc.descriptionDepartamento de Biofísica e Farmacologia Instituto de Biociências Universidade Estadual Paulista (UNESP), Botucatu-SP-
Descrição: dc.descriptionInstituto de Estudos Avançados do Mar (IEAMar) Universidade Estadual Paulista (UNESP), São Vicente-SP-
Descrição: dc.descriptionFAPESP: 2020/10143-7-
Descrição: dc.descriptionFAPESP: 2021/01463-0-
Descrição: dc.descriptionCNPq: 302643/2021-4-
Formato: dc.format231-247-
Idioma: dc.languageen-
Relação: dc.relationBiochimie-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectLys49 myotoxins-
Palavras-chave: dc.subjectMyotoxic inhibitors-
Palavras-chave: dc.subjectPhospholipases A2-
Palavras-chave: dc.subjectPhospholipases A2-like activators-
Palavras-chave: dc.subjectPhospholipases A2-like toxins-
Palavras-chave: dc.subjectSnakebite envenomation-
Título: dc.titleInhibitors and activators for myotoxic phospholipase A2-like toxins from snake venoms – A structural overview-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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