Vitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTiburcio, Felipe Cantore-
Autor(es): dc.creatorCorrea, Viviane da Silva Martins Lopes-
Autor(es): dc.creatorMuller, Kevin Silva-
Autor(es): dc.creatorLeite, Ana Paula Silveira-
Autor(es): dc.creatorPinto, Carina Guidi-
Autor(es): dc.creatorAnselmo, Fabio-
Autor(es): dc.creatorGodinho, Antonio Francisco-
Autor(es): dc.creatorPadovani, Carlos Roberto-
Autor(es): dc.creatorFernandes, Ana Angelica Henrique-
Autor(es): dc.creatorCarvalho, Shelly Favorito de-
Autor(es): dc.creatorMatheus, Selma Maria Michelin-
Data de aceite: dc.date.accessioned2025-08-21T19:37:02Z-
Data de disponibilização: dc.date.available2025-08-21T19:37:02Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/jt/7995780-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298931-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298931-
Descrição: dc.descriptionAtrazine is an herbicide associated with respiratory disorders and the presence of oxidative stress, which can be reversed by association with antioxidant compounds, such as vitamin E. This study aimed to investigate the impact of atrazine (AZ) on the male rat diaphragm muscle and the attenuating effects of vitamin E. Fifty-two male rats were received for 28 days by gavage (n = 13/group): C (control), corn oil; AZ (100 mg/kg); AZE, AZ (100 mg/kg) and vitamin E (200 mg/kg); E, vitamin E (200 mg/kg). Both oxidative stress analysis and morphological analysis of the diaphragm muscle, neuromuscular junction (NMJ), and phrenic nerve were performed. Exposure to AZ caused oxidative stress in muscle fibers, as evidenced by the highest lipid hydroperoxide, and hydrophilic antioxidant capacity values in the AZ group. However, in the AZE group, these values were like those of the C group. The area and diameter of the muscle fiber were only larger in the E group. Exposure to AZ caused oxidative stress in the diaphragm muscle, but vitamin E attenuated these alterations and protected muscle fibers from the oxidative damage. Therefore, vitamin E may serve as a useful attenuating agent against AZ-induced oxidative stress in the skeletal muscle.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionMedical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDivision of Anatomy Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionToxicological Information and Assistance Center (Ciatox) Institute of Biosciences São Paulo State University (UNESP) Botucatu, Brazil unesp.br, BRA-
Descrição: dc.descriptionDivision of Biostatistics Department of Biodiversity and Biostatistics Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDivision of Chemistry and Biochemistry Department of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionElectron Microscopy Center Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionMedical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDivision of Anatomy Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionToxicological Information and Assistance Center (Ciatox) Institute of Biosciences São Paulo State University (UNESP) Botucatu, Brazil unesp.br, BRA-
Descrição: dc.descriptionDivision of Biostatistics Department of Biodiversity and Biostatistics Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDivision of Chemistry and Biochemistry Department of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionElectron Microscopy Center Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationJournal of Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantioxidant-
Palavras-chave: dc.subjectatrazine-
Palavras-chave: dc.subjectherbicide-
Palavras-chave: dc.subjectneuromuscular junction-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectpesticide-
Palavras-chave: dc.subjectskeletal muscle-
Palavras-chave: dc.subjectvitamin E-
Título: dc.titleVitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar Rats-
Tipo de arquivo: dc.typelivro digital-
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