Cardiac biogenic amine profile and its relationship with parameters of cardiovascular disease in obesity

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBelin, Matheus Antônio Filiol-
Autor(es): dc.creatorVieira, Taynara Aparecida-
Autor(es): dc.creatorGrandini, Núbia Alves-
Autor(es): dc.creatorSiqueira, Juliana Silva-
Autor(es): dc.creatorPalacio, Thiago Luiz Novaga-
Autor(es): dc.creatorCruzeiro, Jordanna-
Autor(es): dc.creatorSormani, Luis Eduardo-
Autor(es): dc.creatorTanganini, Murilo Dalarme-
Autor(es): dc.creatorBarbosa, Gabriela Souza-
Autor(es): dc.creatorGregolin, Cristina Schmitt-
Autor(es): dc.creatorde Campos, Dijon Henrique Salomé-
Autor(es): dc.creatorBazan, Silmeia Garcia Zanati-
Autor(es): dc.creatorMinatel, Igor Otávio-
Autor(es): dc.creatorLima, Giuseppina Pace Pereira-
Autor(es): dc.creatorCorrea, Camila Renata-
Data de aceite: dc.date.accessioned2025-08-21T21:16:43Z-
Data de disponibilização: dc.date.available2025-08-21T21:16:43Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.vph.2024.107412-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298904-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298904-
Descrição: dc.descriptionAims: To identify the cardiac biogenic amine profile of obese rats and associate these compounds with parameters of cardiovascular disease. Main methods: Wistar rats (n = 20) were randomly distributed into two groups: control and obese. Obesity was induced by a high-sugar fat diet. Biochemical parameters were evaluated. Doppler Echocardiography and systolic blood pressure; interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), protein carbonylation, ferric reducing antioxidant power (FRAP), and catalase activity were measured in cardiac tissue. HPLC evaluated the cardiac biogenic profile. Data were compared using the Student's T or Mann-Whitney tests and Spearman's correlation at 5% significance. The principal component analysis (PCA) was performed. Key findings: Obesity generated hypertension, cardiac remodeling and dysfunction, and imbalanced all biochemical, inflammatory, and oxidative markers (p < 0.001). Eight biogenic amines were found in cardiac tissue. Obesity increased serotonin and decreased agmatine, putrescine, cadaverine, and spermidine. Serotonin (r = 0.534 to 0.808) was strong and positively correlated with obesity, biochemical parameters, cardiac inflammation, oxidative stress, hypertension, cardiac remodeling, and dysfunction (p < 0.001). Spermidine (r = −0.560 to −0.680), putrescine (r = −0.532 to −0.805), cadaverine (r = −0.534 to −0.860), and agmatine (r = −0.579 to −0.884) were inversely correlated with the same parameters (p < 0.001). PCA allowed for distinguishing the control and obese groups. Significance: There are strong correlations between cardiac biogenic amine levels, cardiac remodeling, and dysfunction resulting from obesity. Conclusion: There is an association between cardiac biogenic amines and cardiovascular disease in obesity. In addition, agmatine, putrescine, cadaverine, and, mainly, serotonin may be new biomarkers for cardiovascular health in obesity and help to improve the diagnosis and treatment of CVD resulting or not from obesity. However, more research is needed to support this conclusion.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Pathology Medical School Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Bioscience São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Pathology Medical School Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Bioscience São Paulo State University (Unesp)-
Descrição: dc.descriptionCNPq: 306640/2023–6-
Idioma: dc.languageen-
Relação: dc.relationVascular Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAgmatine-
Palavras-chave: dc.subjectCardiac dysfunction-
Palavras-chave: dc.subjectCardiac remodeling-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectPolyamines-
Título: dc.titleCardiac biogenic amine profile and its relationship with parameters of cardiovascular disease in obesity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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