Folic acid-conjugated curcumin-loaded bioMOF-101 for breast cancer therapy

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Brasilia (UnB)-
Autor(es): dc.creatorAlves, Renata Carolina-
Autor(es): dc.creatorQuijia, Christian Rafael-
Autor(es): dc.creatorBento da Silva, Patrícia-
Autor(es): dc.creatorFaria, Raquel Santos-
Autor(es): dc.creatorCabral Morais, Amanda Alencar-
Autor(es): dc.creatorVasconcelos Morais, José Athayde-
Autor(es): dc.creatorde Araújo, Henrique Loback Lopes-
Autor(es): dc.creatorFrem, Regina Célia Galvão-
Autor(es): dc.creatorde Azevedo, Ricardo Bentes-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T17:09:27Z-
Data de disponibilização: dc.date.available2025-08-21T17:09:27Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jddst.2023.104702-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298900-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298900-
Descrição: dc.descriptionBreast cancer ranks as the primary cause of cancer-related mortality among women and stands as the fifth leading cause of cancer death overall. Biocompatible metal-organic frameworks (bioMOFs) emerge as highly attractive and promising platforms for efficient drug absorption and delivery. Thus, our objective was to develop drug delivery systems using bioMOF-101 materials, incorporating curcumin (CCM). The materials were enhanced by coating with folate molecules, facilitating targeted delivery to the tumor region. BioMOF-101 was meticulously synthesized, characterized using various techniques, and subsequently subjected to drug encapsulation tests. Remarkably, CCM@bioMOF-101-1D achieved an impressive encapsulation efficiency of 99.42%. To evaluate the impact of the MOF on cell viability, both breast tumor and normal cell lines were examined, revealing that the materials exhibited no toxicity. In vivo studies, bio-MOFs did not induce a reduction in the tumor region; however, the CCM@bioMOF-101-1D/FA caused a reduction in alveolar volume, which is indicative of its effectiveness in the model employed. In conclusion, the matrices studied herein can be considered promising alternatives for the treatment of breast cancer.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences of São Paulo State University (UNESP), Rodovia Araraquara Jau, Km 01 – S/n – Campos Ville, Araraquara-
Descrição: dc.descriptionDepartment of Genetics and Morphology Institute of Biological Sciences University of Brasilia (UnB) Campus Universitario Darcy Ribeiro, Asa Norte, Federal District-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), Prof. Francisco Degni 55, Araraquara-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences of São Paulo State University (UNESP), Rodovia Araraquara Jau, Km 01 – S/n – Campos Ville, Araraquara-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), Prof. Francisco Degni 55, Araraquara-
Descrição: dc.descriptionFAPESP: 2017/26065–2-
Idioma: dc.languageen-
Relação: dc.relationJournal of Drug Delivery Science and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDelivery system-
Palavras-chave: dc.subjectFunctionalization-
Palavras-chave: dc.subjectMetal-organic frameworks-
Título: dc.titleFolic acid-conjugated curcumin-loaded bioMOF-101 for breast cancer therapy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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