Blockade of Inflammatory Markers Attenuates Cardiac Remodeling and Fibrosis in Rats with Supravalvular Aortic Stenosis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorDuchatsch, Francine-
Autor(es): dc.creatorMiotto, Danyelle S.-
Autor(es): dc.creatorTardelli, Lidieli P.-
Autor(es): dc.creatorDionísio, Thiago J.-
Autor(es): dc.creatorCampos, Dijon S.-
Autor(es): dc.creatorSantos, Carlos F.-
Autor(es): dc.creatorOkoshi, Katashi-
Autor(es): dc.creatorAmaral, Sandra L.-
Data de aceite: dc.date.accessioned2025-08-21T20:01:57Z-
Data de disponibilização: dc.date.available2025-08-21T20:01:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biomedicines11123219-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298880-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298880-
Descrição: dc.descriptionSince cardiac inflammation has been considered an important mechanism involved in heart failure, an anti-inflammatory treatment could control cardiac inflammation and mitigate the worsening of cardiac remodeling. This study evaluated the effects of dexamethasone (DEX) and ramipril treatment on inflammation and cardiac fibrosis in an experimental model of heart failure induced by supravalvular aortic stenosis. Wistar rats (21d) were submitted to an aortic stenosis (AS) protocol. After 21 weeks, an echocardiogram and a maximal exercise test were performed, and after 24 weeks, rats were treated with DEX, ramipril or saline for 14d. The left ventricle (LV) was removed for histological and inflammatory marker analyses. The AS group showed exercise intolerance (−32% vs. Sham), higher relative wall thickness (+63%), collagen deposition and capillary rarefaction, followed by cardiac disfunction. Both treatments were effective in reducing cardiac inflammation, but only DEX attenuated the increased relative wall thickness (−17%) and only ramipril reduced LV fibrosis. In conclusion, both DEX and ramipril decreased cardiac inflammatory markers, which probably contributed to the reduced cardiac fibrosis and relative wall thickness; however, treated AS rats did not show any improvement in cardiac function. Despite the complex pharmacological treatment of heart failure, treatment with an anti-inflammatory could delay the patient’s poor prognosis.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESP, Rodovia Washington Luiz, km 235 Monjolinho, 676, SP-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry USP—University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9–75, SP-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, SP-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences São Paulo State University (UNESP), Av. Eng. Luiz Edmundo Carrijo Coube, 14-01—Vargem Limpa, SP-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESP, Rodovia Washington Luiz, km 235 Monjolinho, 676, SP-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, SP-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences São Paulo State University (UNESP), Av. Eng. Luiz Edmundo Carrijo Coube, 14-01—Vargem Limpa, SP-
Descrição: dc.descriptionCAPES: #88882.426901/2019-01-
Descrição: dc.descriptionCAPES: #88882.426908/2019-01-
Descrição: dc.descriptionCAPES: #88887.634301/2021-00-
Descrição: dc.descriptionCAPES: #88887.634304/2021-00-
Idioma: dc.languageen-
Relação: dc.relationBiomedicines-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcardiac remodeling-
Palavras-chave: dc.subjectechocardiogram-
Palavras-chave: dc.subjectglucocorticoids-
Palavras-chave: dc.subjectinflammatory cytokines-
Palavras-chave: dc.subjectleft ventricle-
Título: dc.titleBlockade of Inflammatory Markers Attenuates Cardiac Remodeling and Fibrosis in Rats with Supravalvular Aortic Stenosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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