Prevalence of Cryptococcal Antigenemia and Lateral Flow Assay Accuracy in Severely Immunosuppressed AIDS Patients

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Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorOswaldo Cruz Foundation-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal da Paraíba (UFPB)-
Autor(es): dc.creatorNegri, Adriana Carla Garcia-
Autor(es): dc.creatorNunes, Maína de Oliveira-
Autor(es): dc.creatorLima, Gláucia Moreira Espíndola-
Autor(es): dc.creatorVenturini, James-
Autor(es): dc.creatorde Oliveira, Sandra Maria do Valle Leone-
Autor(es): dc.creatorLazera, Márcia dos Santos-
Autor(es): dc.creatorCarvalho, Lídia Raquel de-
Autor(es): dc.creatorChang, Marilene Rodrigues-
Autor(es): dc.creatorTsujisaki, Rosianne Assis de Sousa-
Autor(es): dc.creatorFrança, Adriana de Oliveira-
Autor(es): dc.creatorMendes, Rinaldo Poncio-
Autor(es): dc.creatorPaniago, Anamaria Mello Miranda-
Data de aceite: dc.date.accessioned2025-08-21T18:11:31Z-
Data de disponibilização: dc.date.available2025-08-21T18:11:31Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jof10070490-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298865-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298865-
Descrição: dc.descriptionThis study aimed to estimate the prevalence of cryptococcal antigenemia detected by lateral flow assay (LFA) in AIDS patients and its accuracy in the diagnosis of cryptococcosis. Conducted at a university hospital in Brazil from March 2015 to July 2017, it included AIDS patients over 18 years old with a CD4+ count ≤ 200 cells/mm3. Cryptococcal antigen (CrAg) detection using LFA and latex agglutination (LA), along with blood and urine cultures, were performed. The reference standard was the identification of Cryptococcus spp. in clinical specimens through microbiological or histopathological examination. Among 230 patients, the prevalence of CrAg detected by LFA (CrAg LFA) was 13.0%. Factors associated with cryptococcal antigenemia included fever, vomiting, seizures, and a lack of antiretroviral therapy. The sensitivity and specificity of CrAg LFA were 83.9% and 98.0%, respectively. The positive predictive value (PPV) was 86.7%, the negative predictive value (NPV) was 97.5%, and overall accuracy was 96.1%. Cross-reactions were observed in patients with histoplasmosis and paracoccidioidmycosis, but not with aspergillosis or positive rheumatoid factor. The study concludes that the LFA is a useful tool for detecting cryptococcal antigenemia in severely immunocompromised AIDS patients due to its high NPV, specificity, and PPV.-
Descrição: dc.descriptionUniversidade Federal de Mato Grosso do Sul-
Descrição: dc.descriptionGraduate Program in Infectious and Parasitic Diseases Faculty of Medicine Federal University of Mato Grosso do Sul, Campo Grande, MS-
Descrição: dc.descriptionMaria Aparecida Pedrossian University Hospital Federal University of Mato Grosso do Sul, MS-
Descrição: dc.descriptionOswaldo Cruz Foundation, Campo Grande, MS-
Descrição: dc.descriptionNational Institute of Infectious Diseases Evandro Chagas Oswaldo Cruz Foundation, RJ-
Descrição: dc.descriptionDepartment of Biostatistics Plant Biology Parasitology and Zoology Bioscience Institute São Paulo State University Campus de Botucatu, SP-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences Food and Nutrition Federal University of Mato Grosso do Sul, MS-
Descrição: dc.descriptionDepartment of Nutrition Health Sciences Center UFB—Universidade Federal da Paraíba, PB-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Biostatistics Plant Biology Parasitology and Zoology Bioscience Institute São Paulo State University Campus de Botucatu, SP-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School São Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Fungi-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcryptococcosis-
Palavras-chave: dc.subjectHIV infection-
Palavras-chave: dc.subjectimmunocromatography-
Palavras-chave: dc.subjectpoint-of-care systems-
Título: dc.titlePrevalence of Cryptococcal Antigenemia and Lateral Flow Assay Accuracy in Severely Immunosuppressed AIDS Patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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