Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorTechnical University of Denmark-
Autor(es): dc.contributorFederal University of Roraima-
Autor(es): dc.contributorAmazonas State University-
Autor(es): dc.contributorDr. Heitor Vieira Dourado Tropical Medicine Foundation-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Oliveira, Isadora Sousa-
Autor(es): dc.creatorAlano-Da-Silva, Nicoly Malachize-
Autor(es): dc.creatorFerreira, Isabela Gobbo-
Autor(es): dc.creatorCerni, Felipe Augusto-
Autor(es): dc.creatorde Almeida Gonçalves Sachett, Jacqueline-
Autor(es): dc.creatorMonteiro, Wuelton Marcelo-
Autor(es): dc.creatorPucca, Manuela Berto-
Autor(es): dc.creatorArantes, Eliane Candiani-
Data de aceite: dc.date.accessioned2025-08-21T21:41:55Z-
Data de disponibilização: dc.date.available2025-08-21T21:41:55Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1678-9199-JVATITD-2023-0046-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298860-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298860-
Descrição: dc.descriptionTityus serrulatus scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While supportive care is the primary treatment modality, moderate and severe cases require antivenom administration despite potential limitations and adverse effects. The remarkable proliferation of T. serrulatus scorpions, attributed to their biology and asexual reproduction, contributes to a high incidence of envenomation. T. serrulatus scorpion venom predominantly consists of short proteins acting as neurotoxins (α and β), that primarily target ion channels. Nevertheless, high molecular weight compounds, including metalloproteases, serine proteases, phospholipases, and hyaluronidases, are also present in the venom. These compounds play a crucial role in envenomation, influencing the severity of symptoms and the spread of venom. This review endeavors to comprehensively understand the T. serrulatus scorpion venom by elucidating the primary high molecular weight compounds and exploring their potential contributions to envenomation. Understanding these compounds’ mechanisms of action can aid in developing more effective treatments and prevention strategies, ultimately mitigating the impact of scorpion envenomation on public health in Brazil.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of BioMolecular Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Biotechnology and Biomedicine Technical University of Denmark-
Descrição: dc.descriptionHealth and Sciences Postgraduate Program Federal University of Roraima, RR-
Descrição: dc.descriptionSchool of Health Sciences Amazonas State University, AM-
Descrição: dc.descriptionDepartment of Teaching and Research Dr. Heitor Vieira Dourado Tropical Medicine Foundation, AM-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University, SP-
Descrição: dc.descriptionFAPESP: 2019/10173-6-
Descrição: dc.descriptionFAPESP: 2020/13176-3-
Descrição: dc.descriptionFAPESP: 2021/11547-7-
Descrição: dc.descriptionFAPESP: 2021/11936-3-
Descrição: dc.descriptionFAPESP: 2022/08964-8-
Descrição: dc.descriptionCNPq: 311434/2021-5-
Idioma: dc.languageen-
Relação: dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCysteine-rich secretory proteins-
Palavras-chave: dc.subjectHyaluronidase-
Palavras-chave: dc.subjectPhospholipase-
Palavras-chave: dc.subjectProteases-
Palavras-chave: dc.subjectTityus serrulatus-
Título: dc.titleUnderstanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.