Past, present, and future of chemically induced hepatocarcinogenesis rodent models: Perspectives concerning classic and new cancer hallmarks

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorRomualdo, Guilherme Ribeiro-
Autor(es): dc.creatorHeidor, Renato-
Autor(es): dc.creatorBacil, Gabriel Prata-
Autor(es): dc.creatorMoreno, Fernando Salvador-
Autor(es): dc.creatorBarbisan, Luís Fernando-
Data de aceite: dc.date.accessioned2025-08-21T15:14:29Z-
Data de disponibilização: dc.date.available2025-08-21T15:14:29Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2023.121994-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298802-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298802-
Descrição: dc.descriptionHepatocellular carcinoma (HCC), the main primary liver cancer, accounts for 5 % of all incident cases and 8.4 % of all cancer-related deaths worldwide. HCC displays a spectrum of environmental risk factors (viral chronic infections, aflatoxin exposure, alcoholic- and nonalcoholic fatty liver diseases) that result in molecular complexity and heterogeneity, contributing to a rising epidemiological burden, poor prognosis, and non-satisfactory treatment options. The emergence of HCC (i.e., hepatocarcinogenesis) is a multistep and complex process that addresses many (epi)genetic alterations and phenotypic traits, the so-called cancer hallmarks. “Polymorphic microbiomes”, “epigenetic reprogramming”, “senescent cells” and “unlocking phenotypic plasticity” are trending hallmarks/enabling features in cancer biology. As the main molecular drivers of HCC are still undruggable, chemically induced in vivo models of hepatocarcinogenesis are useful tools in preclinical research. Thus, this narrative review aimed at recapitulating the basic features of chemically induced rodent models of hepatocarcinogenesis, eliciting their permanent translational value regarding the “classic” and the “new” cancer hallmarks/enabling features. We gathered state-of-art preclinical evidence on non-cirrhotic, inflammation-, alcoholic liver disease- and nonalcoholic fatty liver-associated HCC models, demonstrating that these bioassays indeed express the recently added hallmarks, as well as reflect the interplay between classical and new cancer traits. Our review demonstrated that these protocols remain valuable for translational preclinical application, as they recapitulate trending features of cancer science. Further “omics-based” approaches are warranted while multimodel investigations are encouraged in order to avoid “model-biased” responses.-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School Experimental Research Unit (UNIPEX) Multimodel Drug Screening Platform – Laboratory of Chemically Induced and Experimental Carcinogenesis (MDSP-LCQE), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Biosciences Institute Department of Structural and Functional Biology Laboratory of Chemically Induced and Experimental Carcinogenesis (LCQE), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School, SP-
Descrição: dc.descriptionUniversity of São Paulo (USP) Faculty of Pharmaceutical Sciences Department of Food and Experimental Nutrition Laboratory of Diet Nutrition and Cancer, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School Experimental Research Unit (UNIPEX) Multimodel Drug Screening Platform – Laboratory of Chemically Induced and Experimental Carcinogenesis (MDSP-LCQE), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Biosciences Institute Department of Structural and Functional Biology Laboratory of Chemically Induced and Experimental Carcinogenesis (LCQE), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School, SP-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnimal models-
Palavras-chave: dc.subjectCancer hallmarks-
Palavras-chave: dc.subjectChemicals-
Palavras-chave: dc.subjectHepatocarcinogenesis-
Palavras-chave: dc.subjectHepatocellular carcinoma-
Título: dc.titlePast, present, and future of chemically induced hepatocarcinogenesis rodent models: Perspectives concerning classic and new cancer hallmarks-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.