Cereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Leicester-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPavan, Aline R.-
Autor(es): dc.creatorSmalley, Joshua P.-
Autor(es): dc.creatorPatel, Urvashi-
Autor(es): dc.creatorPytel, Wiktoria A.-
Autor(es): dc.creatordos Santos, Jean Leandro-
Autor(es): dc.creatorCowley, Shaun M.-
Autor(es): dc.creatorSchwabe, John W. R.-
Autor(es): dc.creatorHodgkinson, James T.-
Data de aceite: dc.date.accessioned2025-08-21T22:44:39Z-
Data de disponibilização: dc.date.available2025-08-21T22:44:39Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-04-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d4cc05138f-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298799-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298799-
Descrição: dc.descriptionHistone deacetylase (HDAC) enzymes 1-3 exist in several corepressor complexes and are viable drug targets. To date, proteolysis targeting chimeras (PROTACs) designed to target HDAC1-3 typically exhibit the selective degradation of HDAC3. Herein, we report cereblon-recruiting PROTACs that degrade HDAC1 with selectivity over HDAC3.-
Descrição: dc.descriptionLeicester Institute of Structural and Chemical Biology School of Chemistry University of Leicester, University Road-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionA Department of Molecular and Cell Biology University of Leicester-
Descrição: dc.descriptionLeicester Institute of Structural and Chemical Biology Department of Molecular and Cell Biology University of Leicester-
Descrição: dc.descriptionInstitute of Chemistry Sa˜o Paulo State University (UNESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionInstitute of Chemistry Sa˜o Paulo State University (UNESP)-
Formato: dc.format13879-13882-
Idioma: dc.languageen-
Relação: dc.relationChemical Communications-
???dc.source???: dc.sourceScopus-
Título: dc.titleCereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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