Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Lisbon-
Autor(es): dc.contributorUniversidad Católica de Santa María-
Autor(es): dc.contributorUniversity of KwaZulu-Natal-
Autor(es): dc.contributorUniversity of Barcelona-
Autor(es): dc.creatorRoque-Borda, Cesar Augusto-
Autor(es): dc.creatorPrimo, Laura Maria Duran Gleriani-
Autor(es): dc.creatorMedina-Alarcón, Kaila Petronila-
Autor(es): dc.creatorCampos, Isabella C.-
Autor(es): dc.creatorNascimento, Camila de Fátima-
Autor(es): dc.creatorSaraiva, Mauro M. S.-
Autor(es): dc.creatorBerchieri Junior, Angelo-
Autor(es): dc.creatorFusco-Almeida, Ana Marisa-
Autor(es): dc.creatorMendes-Giannini, Maria José Soares-
Autor(es): dc.creatorPerdigão, João-
Autor(es): dc.creatorPavan, Fernando Rogério-
Autor(es): dc.creatorAlbericio, Fernando-
Data de aceite: dc.date.accessioned2025-08-21T16:05:23Z-
Data de disponibilização: dc.date.available2025-08-21T16:05:23Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-08-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/advs.202410893-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298752-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298752-
Descrição: dc.descriptionPolymicrobial biofilms adhere to surfaces and enhance pathogen resistance to conventional treatments, significantly contributing to chronic infections in the respiratory tract, oral cavity, chronic wounds, and on medical devices. This review examines antimicrobial peptides (AMPs) as a promising alternative to traditional antibiotics for treating biofilm-associated infections. AMPs, which can be produced as part of the innate immune response or synthesized therapeutically, have broad-spectrum antimicrobial activity, often disrupting microbial cell membranes and causing cell death. Many specifically target negatively charged bacterial membranes, unlike host cell membranes. Research shows AMPs effectively inhibit and disrupt polymicrobial biofilms and can enhance conventional antibiotics' efficacy. Preclinical and clinical research is advancing, with animal studies and clinical trials showing promise against multidrug-resistant bacteria and fungi. Numerous patents indicate increasing interest in AMPs. However, challenges such as peptide stability, potential cytotoxicity, and high production costs must be addressed. Ongoing research focuses on optimizing AMP structures, enhancing stability, and developing cost-effective production methods. In summary, AMPs offer a novel approach to combating biofilm-associated infections, with their unique mechanisms and synergistic potential with existing antibiotics positioning them as promising candidates for future treatments.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP), Sao Paulo-
Descrição: dc.descriptioniMed.ULisboa–Institute for Medicines Research Faculty of Pharmacy University of Lisbon-
Descrição: dc.descriptionVicerrectorado de Investigación Universidad Católica de Santa María-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP), Sao Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Agricultural and Veterinarian Sciences, Sao Paulo-
Descrição: dc.descriptionPeptide Science Laboratory School of Chemistry and Physics University of KwaZulu-Natal-
Descrição: dc.descriptionCIBER-BBN Networking Centre on Bioengineering Biomaterials and Nanomedicine and Department of Organic Chemistry University of Barcelona-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP), Sao Paulo-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP), Sao Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Agricultural and Veterinarian Sciences, Sao Paulo-
Descrição: dc.descriptionCAPES: Code-001-
Idioma: dc.languageen-
Relação: dc.relationAdvanced Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantimicrobial alternatives-
Palavras-chave: dc.subjectbiofilms-
Palavras-chave: dc.subjectdrug discovery-
Palavras-chave: dc.subjectpolymicrobial interactions-
Título: dc.titleAntimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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