A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus (OdsH)

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBât. Grégor Mendel-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorINSERM-
Autor(es): dc.creatorBoas Nunes, William Vilas-
Autor(es): dc.creatorOliveira, Daniel Siqueira-
Autor(es): dc.creatorde Rezende Dias, Guilherme-
Autor(es): dc.creatorCarvalho, Antonio Bernardo-
Autor(es): dc.creatorCaruso, Ícaro Putinhon-
Autor(es): dc.creatorBiselli, Joice Matos-
Autor(es): dc.creatorGuegen, Nathalie-
Autor(es): dc.creatorAkkouche, Abdou-
Autor(es): dc.creatorBurlet, Nelly-
Autor(es): dc.creatorVieira, Cristina-
Autor(es): dc.creatorCarareto, Claudia M.A.-
Data de aceite: dc.date.accessioned2025-08-21T15:17:46Z-
Data de disponibilização: dc.date.available2025-08-21T15:17:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/g3journal/jkad299-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298741-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298741-
Descrição: dc.descriptionOdysseus (OdsH) was the first speciation gene described in Drosophila related to hybrid sterility in offspring of mating between Drosophila mauritiana and Drosophila simulans. Its origin is attributed to the duplication of the gene unc-4 in the subgenus Sophophora. By using a much larger sample of Drosophilidae species, we showed that contrary to what has been previously proposed, OdsH origin occurred 62 MYA. Evolutionary rates, expression, and transcription factor-binding sites of OdsH evidence that it may have rapidly experienced neofunctionalization in male sexual functions. Furthermore, the analysis of the OdsH peptide allowed the identification of mutations of D. mauritiana that could result in incompatibility in hybrids. In order to find if OdsH could be related to hybrid sterility, beyond Sophophora, we explored the expression of OdsH in Drosophila arizonae and Drosophila mojavensis, a pair of sister species with incomplete reproductive isolation. Our data indicated that OdsH expression is not atypical in their male-sterile hybrids. In conclusion, we have proposed that the origin of OdsH occurred earlier than previously proposed, followed by neofunctionalization. Our results also suggested that its role as a speciation gene might be restricted to D. mauritiana and D. simulans.-
Descrição: dc.descriptionStockholm Stress Center-
Descrição: dc.descriptionUniversité Claude Bernard Lyon 1-
Descrição: dc.descriptionJilin Provincial Scientific and Technological Development Program-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)-
Descrição: dc.descriptionInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), 2265 Cristóvão Colombo Street-
Descrição: dc.descriptionLaboratoire de Biométrie et Biologie Evolutive UMR 5558 Université de Lyon Université Lyon 1 CNRS Bât. Grégor Mendel, 43 Boulevard 11 Novembre 1918-
Descrição: dc.descriptionDepartamento de Genética Instituto de Biologia Universidade Federal do Rio de Janeiro CCS sl, A2-075, 373 Carlos Chagas Filho Avenue-
Descrição: dc.descriptionFaculté de Médecine iGReD Université Clermont Auvergne CNRS INSERM, 4 Bd Claude Bernard Ferrande-
Descrição: dc.descriptionInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), 2265 Cristóvão Colombo Street-
Descrição: dc.descriptionStockholm Stress Center: 15081-1271.17-
Descrição: dc.descriptionUniversité Claude Bernard Lyon 1: 2020/06238-2-
Descrição: dc.descriptionJilin Provincial Scientific and Technological Development Program: 308020/2021-9-
Idioma: dc.languageen-
Relação: dc.relationG3: Genes, Genomes, Genetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDrosophilidae-
Palavras-chave: dc.subjectgene duplication-
Palavras-chave: dc.subjecthomeodomain-
Palavras-chave: dc.subjectOdsH expression-
Palavras-chave: dc.subjecttranscription factor-
Palavras-chave: dc.subjectunc-4-
Título: dc.titleA comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus (OdsH)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.