Expression of β1- and β2-adrenergic receptors in oral squamous cell carcinoma and their association with psychological and clinical factors

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUNISALESIANO-
Autor(es): dc.creatorSantos-Sousa, Ana Lívia-
Autor(es): dc.creatorKayahara, Giseli Mitsuy-
Autor(es): dc.creatorBastos, Daniela Brito-
Autor(es): dc.creatorSarafim-Silva, Bruna Amélia Moreira-
Autor(es): dc.creatorCrivelini, Marcelo Macedo-
Autor(es): dc.creatorValente, Vítor Bonetti-
Autor(es): dc.creatorCorrente, José Eduardo-
Autor(es): dc.creatorXavier-Júnior, Jose Cândido Caldeira-
Autor(es): dc.creatorMiyahara, Glauco Issamu-
Autor(es): dc.creatorBernabé, Daniel Galera-
Data de aceite: dc.date.accessioned2025-08-21T19:31:16Z-
Data de disponibilização: dc.date.available2025-08-21T19:31:16Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2024.105939-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298735-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298735-
Descrição: dc.descriptionBackground: Psychological stressors have been related to tumor progression through the activation of beta-adrenergic receptors (β-AR) in several types of cancer. Purpose: This study aimed to investigate the expressions of β1- and β2-AR and their association with psychological and clinicopathological variables in patients with oral squamous cell carcinoma. Methods: Tumor samples from 99 patients diagnosed with OSCC were subjected to immunohistochemical reaction to detect the expression of β1-AR and β2-AR. Anxiety and depression symptoms were assessed using the Beck Anxiety Inventory and Beck Depression Inventory (BDI), respectively. The Brunel Mood Scale was used for measuring affective mood states. Results: Univariate analyzes revealed that higher expression of β1-AR was associated with increased alcohol consumption (p = 0.032), higher education (p = 0.042), worse sleep quality (p = 0.044) and increased levels of pain related to the primary tumor (p < 0.001). Higher expression of β2-AR was related with regional metastasis (p = 0.014), increased levels of pain related to the primary tumor (p = 0.044), anxiety (p < 0.001) and depressive (p = 0.010) symptoms and higher mood scores of angry (p = 0.010) and fatigue (p = 0.010). Multivariate analysis identified that patients with advanced clinical stage had lower β1-AR expression (OR=0.145, 95% CI=0.025–0.828, p = 0.003). Higher anxiety symptoms and higher mood fatigue are independent factors for increased β2-AR expression (OR=4256, 95% CI=1439–12606, p = 0.009; OR=3816, 95% CI=1258–11,573, p = 0.018, respectively). Conclusion: This study reveal that anxiety, fatigue symptoms, and clinical staging are associated with tumor expression of beta-adrenergic receptors in patients with oral cancer.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionPsychosomatic Research Center Oral Oncology Center São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionResearch Support Office Botucatu Medical School (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Medicine UNISALESIANO, São Paulo-
Descrição: dc.descriptionPsychosomatic Research Center Oral Oncology Center São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionResearch Support Office Botucatu Medical School (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2016/25255–0-
Descrição: dc.descriptionFAPESP: 2018/06928–9-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnxiety-
Palavras-chave: dc.subjectBeta Adrenergic Receptors-
Palavras-chave: dc.subjectCancer-
Palavras-chave: dc.subjectDepression-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectMood State-
Palavras-chave: dc.subjectOral Cancer-
Palavras-chave: dc.subjectPsychological Distress-
Palavras-chave: dc.subjectSquamous Cell Carcinoma-
Palavras-chave: dc.subjectStress-
Título: dc.titleExpression of β1- and β2-adrenergic receptors in oral squamous cell carcinoma and their association with psychological and clinical factors-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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