Full-thickness burn scar treatment using a combination of microneedling and platelet-rich plasma in animal model

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Jataí - UFJ-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversity of Hartford-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity Center of Mineiros – UNIFIMES-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSantos, Kamylla Caroline-
Autor(es): dc.creatordos Santos, Benedito Matheus-
Autor(es): dc.creatorRibeiro, Maisa-
Autor(es): dc.creatorde Miranda Moraes, Júlia-
Autor(es): dc.creatorCagnini, Didier Quevedo-
Autor(es): dc.creatorLiebano, Richard Eloin-
Autor(es): dc.creatorAraujo, Gustavo Henrique Marques-
Data de aceite: dc.date.accessioned2025-08-21T15:16:56Z-
Data de disponibilização: dc.date.available2025-08-21T15:16:56Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.tice.2024.102610-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298727-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298727-
Descrição: dc.descriptionMicroneedling (MA) and platelet-rich plasma (PRP) therapies have shown potential for enhancing scar repair through collagen production and growth factor release, yet their effects on full-thickness burn scars remain underexplored. This study evaluated the impact of MA, PRP, and combined MA + PRP treatments on scar healing in a rat model of full-thickness burns. Fifty adult rats were divided into four groups: control, MA, PRP, and MA + PRP. Treatments were administered 21 days post-burn, and animals were evaluated at 14- and 21-days post-treatment. Macroscopic, histopathological, and morphometric analyses were performed to assess epithelialization, extracellular matrix (ECM) organization, and collagen deposition. The combination of MA + PRP demonstrated superior outcomes, showing enhanced ECM organization, significant collagen deposition, increased angiogenesis, and an improved inflammatory profile with mononuclear cell infiltration. Morphometric analysis confirmed a substantial increase in collagen content, particularly in the MA + PRP group, supporting improved tissue remodeling and scar maturation. These findings suggest that combined MA + PRP therapy may be a promising approach for promoting effective and accelerated burn scar healing. Further research is warranted to optimize protocols for clinical application.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSpecial Academic Unit of Animal Bioscience Federal University of Jataí - UFJ, Jataí, Go-
Descrição: dc.descriptionPhysiotherapeutic Resources Research Laboratory Department of Physical Therapy Federal University of São Carlos - UFSCar, SP-
Descrição: dc.descriptionUniversity of Hartford-
Descrição: dc.descriptionDepartment of Microbiology Institute of Biomedical Sciences University of São Paulo - USP, SP-
Descrição: dc.descriptionUniversity Center of Mineiros – UNIFIMES, Mineiros, Go-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science São Paulo State University - Unesp, SP-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science São Paulo State University - Unesp, SP-
Idioma: dc.languageen-
Relação: dc.relationTissue and Cell-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBurn scar repair-
Palavras-chave: dc.subjectCollagen deposition-
Palavras-chave: dc.subjectExtracellular matrix (ECM) remodeling-
Palavras-chave: dc.subjectMicroneedling (MA)-
Palavras-chave: dc.subjectPlatelet-rich plasma (PRP)-
Título: dc.titleFull-thickness burn scar treatment using a combination of microneedling and platelet-rich plasma in animal model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.