Short-term exercise counteracts accelerated ageing impacts on physical performance and liver health in mice

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorVirginia Tech Carilion-
Autor(es): dc.creatorPinto, Ana P.-
Autor(es): dc.creatorMuñoz, Vitor R.-
Autor(es): dc.creatorTavares, Maria Eduarda A.-
Autor(es): dc.creatorNeto, Ivo V. de Sousa-
Autor(es): dc.creatordos Santos, Jonathas R.-
Autor(es): dc.creatorRodrigues, Guilherme S.-
Autor(es): dc.creatorCarolino, Ruither O. Gomes-
Autor(es): dc.creatorAlberici, Luciane C.-
Autor(es): dc.creatorSimabuco, Fernando M.-
Autor(es): dc.creatorTeixeira, Giovana R.-
Autor(es): dc.creatorPauli, José R.-
Autor(es): dc.creatorde Moura, Leandro P.-
Autor(es): dc.creatorCintra, Dennys E.-
Autor(es): dc.creatorRopelle, Eduardo R.-
Autor(es): dc.creatorFreitas, Ellen C.-
Autor(es): dc.creatorRivas, Donato A.-
Autor(es): dc.creatorda Silva, Adelino S. R.-
Data de aceite: dc.date.accessioned2025-08-21T21:28:18Z-
Data de disponibilização: dc.date.available2025-08-21T21:28:18Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/1440-1681.70001-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298708-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298708-
Descrição: dc.descriptionSenescence impairs liver physiology, mitochondrial function and circadian regulation, resulting in systemic metabolic dysregulation. Given the limited research on the effects of combined exercise on an ageing liver, this study aimed to evaluate its impact on liver metabolism, circadian rhythms and mitochondrial function in senescence-accelerated mouse-prone 8 (SAMP8) and senescence-accelerated mouse-resistant 1 (SAMR1) mice. Histological, reverse transcription quantitative polymerase chain reaction (RT-qPCR) and immunoblotting analyses were conducted, supplemented by transcriptomic data sets and AML12 hepatocyte studies. Sedentary SAMP8 mice exhibited decreased muscle strength, reduced mitochondrial complex I levels and increased lipid droplet accumulation. In contrast, combined exercise mitigated muscle strength loss, upregulated proteins involved in mitochondrial complexes (CIII, CIV, CV) and increased Bmal1 messenger RNA (mRNA) expression in the liver. These molecular adaptations are associated with healthier liver phenotypes and may influence metabolic function and cellular longevity. Notably, elevated lipid content in aged mice was reduced post-exercise, indicating liver benefits even after a relatively short intervention. The combined exercise regimen did not improve aerobic capacity, likely due to the low volume and brief duration of running. Moreover, no significant effects were observed in SAMR1 mice, possibly because the training intensity was insufficient for younger, healthier animals. These findings underscore the potential of combined strength and endurance exercise to attenuate age-related liver dysfunction, particularly in ageing populations.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Physical Education State University of São Paulo (UNESP)-
Descrição: dc.descriptionMulticentric Program of Postgraduate in Physiological Sciences School of Dentistry of Araçatuba São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biomolecular Sciences School of Pharmaceutical Sciences of Ribeirao Preto University of São Paulo-FCFRP USP-
Descrição: dc.descriptionDepartment of Internal Medicine Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionLaboratory of Molecular Biology of Exercise (LaBMEx) School of Applied Sciences University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Biochemistry Federal University of São Paulo (UNIFESP)-
Descrição: dc.descriptionNutrigenomics and Lipids Research Center CELN School of Applied Sciences UNICAMP-
Descrição: dc.descriptionDepartment of Health Sciences Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionCenter for Exercise Medicine Research Fralin Biomedical Research Institute Virginia Tech Carilion-
Descrição: dc.descriptionPostgraduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Physical Education State University of São Paulo (UNESP)-
Descrição: dc.descriptionMulticentric Program of Postgraduate in Physiological Sciences School of Dentistry of Araçatuba São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationClinical and Experimental Pharmacology and Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectaging-
Palavras-chave: dc.subjectexercise-
Palavras-chave: dc.subjectlipid droplet-
Palavras-chave: dc.subjectliver-
Palavras-chave: dc.subjectsenescence-
Título: dc.titleShort-term exercise counteracts accelerated ageing impacts on physical performance and liver health in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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