The LINC complex in blood vessels: from physiology to pathological implications in arterioles

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidad de La República-
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversity Medical Centre Groningen (UMCG)-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorQLD-
Autor(es): dc.contributorSchool of Medicine and Health Sciences-
Autor(es): dc.contributorUniversity of Macau-
Autor(es): dc.contributorColumbia University-
Autor(es): dc.contributorInstitute for Molecular Medicine-
Autor(es): dc.creatorFerreira, Gonzalo-
Autor(es): dc.creatorCardozo, Romina-
Autor(es): dc.creatorChavarria, Luisina-
Autor(es): dc.creatorSantander, Axel-
Autor(es): dc.creatorSobrevia, Luis-
Autor(es): dc.creatorChang, Wakam-
Autor(es): dc.creatorGundersen, Gregg-
Autor(es): dc.creatorNicolson, Garth L.-
Data de aceite: dc.date.accessioned2025-08-21T18:16:57Z-
Data de disponibilização: dc.date.available2025-08-21T18:16:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1113/JP285906-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298687-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298687-
Descrição: dc.descriptionThe LINC (linker of nucleoskeleton and cytoskeleton) complex is a critical component of the cellular architecture that bridges the nucleoskeleton and cytoskeleton and mediates mechanotransduction to and from the nucleus. Though it plays important roles in all blood vessels, it is in arterioles that this complex plays a pivotal role in maintaining endothelial cell integrity, regulating vascular tone, forming new microvessels and modulating responses to mechanical and biochemical stimuli. It is also important in vascular smooth muscle cells and fibroblasts, where it possibly plays a role in the contractile to secretory phenotypic transformation during atherosclerosis and vascular ageing, and in fibroblasts' migration and inflammatory responses in the adventitia. Physiologically, the LINC complex contributes to the stability of arteriolar structure, adaptations to changes in blood flow and injury repair mechanisms. Pathologically, dysregulation or mutations in LINC complex components can lead to compromised endothelial function, vascular remodelling and exacerbation of cardiovascular diseases such as atherosclerosis (arteriolosclerosis). This review summarizes our current understanding of the roles of the LINC complex in cells from arterioles, highlighting its most important physiological functions, exploring its implications for vascular pathology and emphasizing some of its functional characteristics in endothelial cells. By elucidating the LINC complex's role in health and disease, we aim to provide insights that could improve future therapeutic strategies targeting LINC complex-related vascular disorders. (Figure presented.).-
Descrição: dc.descriptionDepartment of Biophysics Faculty of Medicine Universidad de La República-
Descrição: dc.descriptionCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionDepartment of Pathology and Medical Biology Division of Pathology University of Groningen University Medical Centre Groningen (UMCG)-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Medicine and Biomedical Sciences University of Queensland Centre for Clinical Research (UQCCR) University of Queensland QLD, Herston-
Descrição: dc.descriptionTecnologico de Monterrey Eutra The Institute for Obesity Research (IOR) School of Medicine and Health Sciences, Nuevo León-
Descrição: dc.descriptionFaculty of Health Sciences University of Macau-
Descrição: dc.descriptionDepartment of Pathology and Cell Biology Columbia University-
Descrição: dc.descriptionDepartment of Molecular Pathology Institute for Molecular Medicine-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectarterioles-
Palavras-chave: dc.subjectendothelial cells-
Palavras-chave: dc.subjectLINC complex-
Título: dc.titleThe LINC complex in blood vessels: from physiology to pathological implications in arterioles-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.