Nano-in-microparticles approach: Targeted gastric ulcer therapy using trans-resveratrol nanoparticles encapsulated in hyaluronic acid and alginate microparticles

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributori3S - Instituto de Investigação e Inovação em Saúde-
Autor(es): dc.contributorINEB - Instituto de Engenharia Biomédica-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.creatorSpósito, Larissa-
Autor(es): dc.creatorMorais-Silva, Gessynger-
Autor(es): dc.creatorFonseca, Diana-
Autor(es): dc.creatorNeves, Matheus Morais-
Autor(es): dc.creatorVieira Silva, Murilo-
Autor(es): dc.creatorBauab, Taís Maria-
Autor(es): dc.creatorParreira, Paula-
Autor(es): dc.creatorMartins, M. Cristina L.-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T17:17:59Z-
Data de disponibilização: dc.date.available2025-08-21T17:17:59Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2025.141010-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298680-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298680-
Descrição: dc.descriptionGastric ulcers affect 4 million people worldwide and occur when the stomach's defenses are compromised, allowing harmful agents, such as nonsteroidal anti-inflammatory drugs and Helicobacter pylori, to damage the tissue. The naturally occurring polyphenol, trans-resveratrol (RESV), demonstrates promising potential for treating gastric diseases. However, its therapeutic application is limited by its photosensitivity and solubility. To overcome these challenges, RESV was encapsulated in a new nano-in-microparticle system comprised of chitosan nanoparticles incorporated into hyaluronic acid and alginate microparticles (RESV-MNP). RESV-MNP exhibited spherical morphology (~2 μm) and encapsulation efficiency of 79 %, releasing about 41 % of RESV within 24 h, showing a prolonged release profile compared to the free drug. Additionally, RESV-MNP interacted with porcine mucin in an acid environment. RESV-MNP showed no toxicity against AGS/MKN-74 cell lines in vitro and in acute toxicity tests using Galleria mellonella and hemolysis. RESV-MNP presented a minimum inhibitory and bactericidal concentration (MIC/MBC) of 3.9 μg/mL, eradicating H. pylori after 24 h. At 2×MIC, RESV-MNP completely eradicated H. pylori biofilm. In an in vitro infection assay, RESV-MNP reduced H. pylori load. The formulation effectively reduced the mortality rate of H. pylori-infected larvae in the G. mellonella model. Furthermore, RESV-MNP demonstrated gastroprotective effects, reducing the extent and severity of indomethacin-gastric lesions in rats.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionEuropean Commission-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptioni3S - Instituto de Investigação e Inovação em Saúde, Rua Alfredo Allen, 208-
Descrição: dc.descriptionINEB - Instituto de Engenharia Biomédica, Rua Alfredo Allen, 208-
Descrição: dc.descriptionBiotechnology in Experimental Models Laboratory - LABME Federal University of Uberlândia, MG-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionFAPESP: 2019/09597-6-
Descrição: dc.descriptionFAPESP: 2021/11681-5-
Descrição: dc.descriptionEuropean Commission: 951723-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDrug delivery system-
Palavras-chave: dc.subjectGastric disease-
Palavras-chave: dc.subjectHelicobacter pylori-
Título: dc.titleNano-in-microparticles approach: Targeted gastric ulcer therapy using trans-resveratrol nanoparticles encapsulated in hyaluronic acid and alginate microparticles-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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