Antibody Titer Prediction from Serum Immunodiffusion Test of Patients with Paracoccidioidomycosis Using Infrared Spectroscopy and Chemometrics

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Autor(es): dc.contributorUniversidade Federal do Rio Grande do Sul—UFRGS-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de Santa Cruz do Sul—UNISC-
Autor(es): dc.creatorKoehler, Alessandra-
Autor(es): dc.creatorScroferneker, Maria Lúcia-
Autor(es): dc.creatorde Moraes, Paulo Cezar-
Autor(es): dc.creatorPereira, Beatriz Aparecida Soares-
Autor(es): dc.creatorCavalcante, Ricardo de Souza-
Autor(es): dc.creatorMendes, Rinaldo Pôncio-
Autor(es): dc.creatorCorbellini, Valeriano Antonio-
Data de aceite: dc.date.accessioned2025-08-21T17:29:53Z-
Data de disponibilização: dc.date.available2025-08-21T17:29:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/analytica4030028-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298666-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298666-
Descrição: dc.descriptionParacoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus Paracoccidioides. Serological tests are auxiliary in the diagnosis of PCM. However, the lack of standardization is a central problem in serodiagnosis and antibody titration. The objective of this study was to propose a methodology based on Fourier transform infrared spectroscopy (FTIR) for predicting antibody titers in patients with PCM. A total of 118 serum samples from patients with PCM were included, for which antibody titration using double immunodiffusion (DID) was previously performed. Serum samples were analyzed by attenuated total reflection (ATR)-FTIR and a supervised analysis with partial least squares regression (PLS) was used to predict the antibody titers. The PLS model with two latent variables and with the use of one orthogonal signal correction (OSC) showed a determination coefficient (R2) higher than 0.9999 for both the calibration and prediction set. The model was able to predict the antibody titers from patients with PCM with a minimal error. Therefore, modeling with FTIR/ATR and multivariate calibration proved to be a fast and highly accurate method for antibody titration, replacing the need for antigen production and performance of traditional serological tests.-
Descrição: dc.descriptionPostgraduate Program of Medicine: Medical Sciences Universidade Federal do Rio Grande do Sul—UFRGS-
Descrição: dc.descriptionDepartment of Microbiology Immunology and Parasitology ICBS Universidade Federal do Rio Grande do Sul—UFRGS-
Descrição: dc.descriptionTropical Diseases Area School of Medicine Universidade Estadual Paulista—UNESP-
Descrição: dc.descriptionDepartment of Sciences Humanities and Education Health Promotion Environmental Technology Universidade de Santa Cruz do Sul—UNISC-
Descrição: dc.descriptionTropical Diseases Area School of Medicine Universidade Estadual Paulista—UNESP-
Formato: dc.format385-396-
Idioma: dc.languageen-
Relação: dc.relationAnalytica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantibody titration-
Palavras-chave: dc.subjectFTIR spectroscopy-
Palavras-chave: dc.subjectimmunodiffusion-
Palavras-chave: dc.subjectparacoccidioidomycosis-
Palavras-chave: dc.subjectserodiagnosis-
Título: dc.titleAntibody Titer Prediction from Serum Immunodiffusion Test of Patients with Paracoccidioidomycosis Using Infrared Spectroscopy and Chemometrics-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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