A novel GLUT-4 electrochemical immunosensor based on a poly(thionine)-gold nanoparticle nanocomposite: Combining complex capacitance and dissolved oxygen to obtain an analytical signal

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorMax-Planck Institute for Chemical Energy Conversion-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorOlean-Oliveira, André-
Autor(es): dc.creatorSeraphim, Patrícia Monteiro-
Autor(es): dc.creatorPortugal, Miquéias L.-
Autor(es): dc.creatorTeixeira, Marcos F.S.-
Data de aceite: dc.date.accessioned2025-08-21T21:36:10Z-
Data de disponibilização: dc.date.available2025-08-21T21:36:10Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bios.2025.117219-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298662-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298662-
Descrição: dc.descriptionDetection of glucose transporter 4 (GLUT4) is essential for understanding various physiological and pathological processes. This work reports the development of a novel electrochemical immunosensor for the direct detection of GLUT4, employing dissolved oxygen as a redox probe. This molecular oxygen-sensitive response is mediated by a redox-conductive polymer based on thionine. The sensor platform was fabricated via a one-step electropolymerization of thionine and gold nanoparticles (AuNPs) onto a platinum screen-printed electrode (Olean-Oliveira et al., 2022a). The immunosensor was then constructed by physical adsorption of a GLUT4 antibody onto the poly(thionine)-AuNP composite surface. This label-free approach eliminates the need for secondary antibodies or enzymes. The immunosensor performance was evaluated using electrochemical impedance spectroscopy (EIS). The sensing mechanism relies on impedance changes; increasing GLUT4 concentrations lead to increased impedance due to enhanced surface blocking upon GLUT4-antibody binding. This interaction impedes oxygen diffusion to the polymer redox sites, resulting in increased electrical resistance. Analysis of the redox capacitance as a function of frequency demonstrates a decrease in the capacitive arc with increasing GLUT4 concentration.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionMax-Planck Institute for Chemical Energy Conversion-
Descrição: dc.descriptionDepartment of Physiotherapy School of Science and Technology Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry School of Science and Technology Sao Paulo State University (UNESP), Rua Roberto Simonsen, 305, SP-
Descrição: dc.descriptionDepartment of Physiotherapy School of Science and Technology Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry School of Science and Technology Sao Paulo State University (UNESP), Rua Roberto Simonsen, 305, SP-
Descrição: dc.descriptionFAPESP: 2004/10130-0-
Descrição: dc.descriptionFAPESP: 2024/08769-6-
Descrição: dc.descriptionCNPq: 308232/2023-2-
Descrição: dc.descriptionCAPES: 88882.434480/2019–01-
Idioma: dc.languageen-
Relação: dc.relationBiosensors and Bioelectronics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnti-GLUT4-
Palavras-chave: dc.subjectElectrochemical impedance spectroscopy-
Palavras-chave: dc.subjectGlucose transporters-
Palavras-chave: dc.subjectGold nanoparticle polymer-
Palavras-chave: dc.subjectImmunosensor-
Palavras-chave: dc.subjectPhysiological protocol-
Título: dc.titleA novel GLUT-4 electrochemical immunosensor based on a poly(thionine)-gold nanoparticle nanocomposite: Combining complex capacitance and dissolved oxygen to obtain an analytical signal-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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