The Addition of Hydroxyapatite Nanoparticles on Implant Surfaces Modified by Zirconia Blasting and Acid Etching to Enhance Peri-Implant Bone Healing

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTufts University-
Autor(es): dc.contributorUniversity of Guarulhos (UnG)-
Autor(es): dc.creatorToscano, Ricardo Alves-
Autor(es): dc.creatorBarbosa, Stéfany-
Autor(es): dc.creatorCampos, Larissa Gabriele-
Autor(es): dc.creatorde Sousa, Cecília Alves-
Autor(es): dc.creatorDallazen, Eduardo-
Autor(es): dc.creatorMourão, Carlos Fernando-
Autor(es): dc.creatorShibli, Jamil Awad-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorFaverani, Leonardo P.-
Autor(es): dc.creatorAssunção, Wirley Goncalves-
Data de aceite: dc.date.accessioned2025-08-21T18:48:33Z-
Data de disponibilização: dc.date.available2025-08-21T18:48:33Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms25137321-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298644-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298644-
Descrição: dc.descriptionThis study investigated the impact of adding hydroxyapatite nanoparticles to implant surfaces treated with zirconia blasting and acid etching (ZiHa), focusing on structural changes and bone healing parameters in low-density bone sites. The topographical characterization of titanium discs with a ZiHa surface and a commercially modified zirconia-blasted and acid-etched surface (Zi) was performed using scanning electron microscopy, profilometry, and surface-free energy. For the in vivo assessment, 22 female rats were ovariectomized and kept for 90 days, after which one implant from each group was randomly placed in each tibial metaphysis of the animals. Histological and immunohistochemical analyses were performed at 14 and 28 days postoperatively (decalcified lab processing), reverse torque testing was performed at 28 days, and histometry from calcified lab processing was performed at 60 days The group ZiHa promoted changes in surface morphology, forming evenly distributed pores. For bone healing, ZiHa showed a greater reverse torque, newly formed bone area, and bone/implant contact values compared to group Zi (p < 0.05; t-test). Qualitative histological and immunohistochemical analyses showed higher features of bone maturation for ZiHa on days 14 and 28. This preclinical study demonstrated that adding hydroxyapatite to zirconia-blasted and acid-etched surfaces enhanced peri-implant bone healing in ovariectomized rats. These findings support the potential for improving osseointegration of dental implants, especially in patients with compromised bone metabolism.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Sao Paulo State University UNESP Aracatuba School of Dentistry-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Sao Paulo State University UNESP Aracatuba School of Dentistry-
Descrição: dc.descriptionDepartment of Periodontology School of Dentistry Tufts University-
Descrição: dc.descriptionDental Research Division Department of Periodontology and Oral Implantology University of Guarulhos (UnG)-
Descrição: dc.descriptionDepartment of Basic Science Sao Paulo State University UNESP Aracatuba School of Dentistry-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Sao Paulo State University UNESP Aracatuba School of Dentistry-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Sao Paulo State University UNESP Aracatuba School of Dentistry-
Descrição: dc.descriptionDepartment of Basic Science Sao Paulo State University UNESP Aracatuba School of Dentistry-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjecthydroxyapatite-
Palavras-chave: dc.subjectosseointegration-
Título: dc.titleThe Addition of Hydroxyapatite Nanoparticles on Implant Surfaces Modified by Zirconia Blasting and Acid Etching to Enhance Peri-Implant Bone Healing-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.