Feet and legs malformation in Nellore cattle: genetic analysis and prioritization of GWAS results

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMichigan State University-
Autor(es): dc.contributorUniversity of Guelph-
Autor(es): dc.contributorViçosa Federal University-
Autor(es): dc.contributorGenSys Associated Consultants-
Autor(es): dc.contributorResearcher at National Council for Scientific and Technological Development (CNPq)-
Autor(es): dc.creatorSilva, Thales de Lima-
Autor(es): dc.creatorGondro, Cedric-
Autor(es): dc.creatorFonseca, Pablo Augusto de Souza-
Autor(es): dc.creatorSilva, Delvan Alves da-
Autor(es): dc.creatorVargas, Giovana-
Autor(es): dc.creatorNeves, Haroldo Henrique de Rezende-
Autor(es): dc.creatorCarvalho Filho, Ivan-
Autor(es): dc.creatorTeixeira, Caio de Souza-
Autor(es): dc.creatorAlbuquerque, Lucia Galvão de-
Autor(es): dc.creatorCarvalheiro, Roberto-
Data de aceite: dc.date.accessioned2025-08-21T21:13:07Z-
Data de disponibilização: dc.date.available2025-08-21T21:13:07Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fgene.2023.1118308-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298606-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298606-
Descrição: dc.descriptionBeef cattle affected by feet and legs malformations (FLM) cannot perform their productive and reproductive functions satisfactorily, resulting in significant economic losses. Accelerated weight gain in young animals due to increased fat deposition can lead to ligaments, tendon and joint strain and promote gene expression patterns that lead to changes in the normal architecture of the feet and legs. The possible correlated response in the FLM due to yearling weight (YW) selection suggest that this second trait could be used as an indirect selection criterion. Therefore, FLM breeding values and the genetic correlation between FLM and yearling weight (YW) were estimated for 295,031 Nellore animals by fitting a linear-threshold model in a Bayesian approach. A genome-wide association study was performed to identify genomic windows and positional candidate genes associated with FLM. The effects of single nucleotide polymorphisms (SNPs) on FLM phenotypes (affected or unaffected) were estimated using the weighted single-step genomic BLUP method, based on genotypes of 12,537 animals for 461,057 SNPs. Twelve non-overlapping windows of 20 adjacent SNPs explaining more than 1% of the additive genetic variance were selected for candidate gene annotation. Functional and gene prioritization analysis of candidate genes identified six genes (ATG7, EXT1, ITGA1, PPARD, SCUBE3, and SHOX) that may play a role in FLM expression due to their known role in skeletal muscle development, aberrant bone growth, lipid metabolism, intramuscular fat deposition and skeletogenesis. Identifying genes linked to foot and leg malformations enables selective breeding for healthier herds by reducing the occurrence of these conditions. Genetic markers can be used to develop tests that identify carriers of these mutations, assisting breeders in making informed breeding decisions to minimize the incidence of malformations in future generations, resulting in greater productivity and animal welfare.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Animal Science School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDepartment of Animal Science College of Agriculture and Natural Resources Michigan State University-
Descrição: dc.descriptionCentre for Genetic Improvement of Livestock Department of Animal Biosciences University of Guelph-
Descrição: dc.descriptionDepartment of Animal Science Viçosa Federal University-
Descrição: dc.descriptionGenSys Associated Consultants-
Descrição: dc.descriptionResearcher at National Council for Scientific and Technological Development (CNPq)-
Descrição: dc.descriptionDepartment of Animal Science School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp), SP-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Genetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBos taurus indicus-
Palavras-chave: dc.subjectcandidate genes-
Palavras-chave: dc.subjectfunctional trait-
Palavras-chave: dc.subjectlocomotion-
Palavras-chave: dc.subjectwelfare-
Título: dc.titleFeet and legs malformation in Nellore cattle: genetic analysis and prioritization of GWAS results-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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