A new hydrogel containing a proanthocyanidin polymer-rich extract of Commiphora leptophloeos for treating vulvovaginal candidiasis: Preclinical results using the alternative model of Galleria mellonella

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Autor(es): dc.contributorFederal University of Rio Grande do Norte-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Rio-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorComplutense University of Madrid-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.creatorDantas-Medeiros, Renato-
Autor(es): dc.creatorMarena, Gabriel Davi-
Autor(es): dc.creatorAraújo, Victor Hugo Sousa-
Autor(es): dc.creatorBezerra Neto, Francisco de Assis-
Autor(es): dc.creatorZanatta, Ana Caroline-
Autor(es): dc.creatorLopes, Norberto Peporine-
Autor(es): dc.creatorBermejo, Paulina-
Autor(es): dc.creatorGuerra, José Antonio-
Autor(es): dc.creatorBedoya, Luis Miguel-
Autor(es): dc.creatorFonseca-Santos, Bruno-
Autor(es): dc.creatorAmorim-Carmo, Bruno-
Autor(es): dc.creatorFernandes-Pedrosa, Matheus de Freitas-
Autor(es): dc.creatorChaves, Guilherme Maranhão-
Autor(es): dc.creatorBauab, Tais Maria-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorZucolotto, Silvana Maria-
Data de aceite: dc.date.accessioned2025-08-21T16:01:25Z-
Data de disponibilização: dc.date.available2025-08-21T16:01:25Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jddst.2023.104531-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298596-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298596-
Descrição: dc.descriptionIn the present study, we aimed to develop and characterize a hydrogel formulation containing a proanthocyanidin polymer-rich extract of Commiphora leptophloeos and investigate its toxicity and antifungal effect in vitro and in vivo on Galleria mellonella infected with Candida albicans larvae. The extract (4%) was incorporated into a hydrogel formulation based on chitosan (1.0%) and poloxamer 407 (18%), and evaluated by physical (organoleptic characteristics, rheological tests, and texture profile analysis), chemical (proanthocyanidin content and pH), and microbiological parameters. Under the study conditions, the new hydrogel displayed good physicochemical and microbiological stability for 3 months at 25 °C. Both the extract and the hydrogel were evaluated regarding their safety and efficacy in vitro on uterine/endometrial epithelial cells (HEC-1A) and against Candida spp. strains, as well as in vivo in the alternative model of acute toxicity and C. albicans-infection in G. mellonella. The results showed that the hydrogel is biocompatible with the vaginal environment, becoming more viscous with increasing temperature, and has higher antifungal potential compared to a free extract at all tested concentrations in vitro (2172–33.9 μg/mL), and in vivo at the dose of 125 mg/kg. Overall, the data provide evidence of the potential of the new hydrogel to be applied in treating vulvovaginal candidiasis.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniversidad Complutense de Madrid-
Descrição: dc.descriptionUniversidade Federal do Rio Grande do Norte-
Descrição: dc.descriptionUniversity of South Alabama-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences Faculty of Pharmacy Federal University of Rio Grande do Norte-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Campus Araraquara, São Paulo State-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP), Campus Araraquara, São Paulo State-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses Federal University of Rio, Grande do Norte-
Descrição: dc.descriptionDepartment of Biomolecular Sciences Faculty of Pharmaceutical Sciences of Ribeirao Preto São Paulo University, Ribeirão Preto, São Paulo State-
Descrição: dc.descriptionDepartment of Pharmacology Pharmacognosy and Botany Faculty of Pharmacy Complutense University of Madrid-
Descrição: dc.descriptionDepartment of Biotechnology Health Sciences Institute Federal University of Bahia-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Campus Araraquara, São Paulo State-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP), Campus Araraquara, São Paulo State-
Idioma: dc.languageen-
Relação: dc.relationJournal of Drug Delivery Science and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBurseraceae-
Palavras-chave: dc.subjectCondensed tannin physicochemical stability-
Palavras-chave: dc.subjectFungal infections-
Palavras-chave: dc.subjectImburana-
Palavras-chave: dc.subjectResistance-
Título: dc.titleA new hydrogel containing a proanthocyanidin polymer-rich extract of Commiphora leptophloeos for treating vulvovaginal candidiasis: Preclinical results using the alternative model of Galleria mellonella-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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