Sunflower Oil and Cholesterol Nanoemulsion: A Novel Carrier for Micafungin to Combat Multi-Resistant Candida auris

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Autor(es): dc.contributorHealth Research Institute La Fe-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorLa Fe Hospital-
Autor(es): dc.contributorUniversity of Valencia-
Autor(es): dc.contributorUniversity and Polytechnic La Fe Hospital-
Autor(es): dc.creatorMarena, Gabriel Davi-
Autor(es): dc.creatorLópez, Alejandro-
Autor(es): dc.creatorCarvalho, Gabriela Corrêa-
Autor(es): dc.creatorMarín, María del Pilar-
Autor(es): dc.creatorPérez Ruiz, María Dolores-
Autor(es): dc.creatorPérez-Royo, Jose Manuel-
Autor(es): dc.creatorTormo-Mas, María Ángeles-
Autor(es): dc.creatorBernabé, Patricia-
Autor(es): dc.creatorValentín, Eulogio-
Autor(es): dc.creatorBauab, Taís Maria-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorPemán, Javier-
Autor(es): dc.creatorRuiz-Gaitán, Alba-
Data de aceite: dc.date.accessioned2025-08-21T22:46:00Z-
Data de disponibilização: dc.date.available2025-08-21T22:46:00Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pathogens13070549-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298563-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298563-
Descrição: dc.descriptionCandida auris is an emerging, multidrug-resistant yeast that causes systemic infections, mainly in hospitalized or immunosuppressed patients. This pathogen has a high mortality and morbidity rate. This study aims to evaluate the antifungal potential of micafungin (MICA) encapsulated in a nanoemulsion (NEM) against four clades of C. auris and other non-C. auris species. The antifungal potential of MICA and NEM was evaluated by determining mature biofilm inhibition (0.78–50 µg/mL). The antifungal activities of MICA and NEM (5.92 mg/Kg) were evaluated using an in vivo model of Galleria mellonella. The results showed that NEM intensified the antibiofilm action of MICA, especially in 48 h mature biofilms. In vivo results displayed a higher effectiveness of NEM against all clades of C. auris tested, inhibiting the fungal load in the hemolymph and tissues of G. mellonella with a difference of 3 log10. In addition, C. auris infection caused granulomas surrounded by hemocytes, mainly at the lower and upper ends. Conversely, C. albicans developed pseudohyphae, biofilms, filaments, and chlamydospores. In conclusion, encapsulation of MICA in a nanoemulsion enhances its antifungal activity against mature biofilms of C. auris. This strategy may be considered a therapeutic approach for the control of infections and the dissemination of this new global health threat.-
Descrição: dc.descriptionInstituto de Salud Carlos III-
Descrição: dc.descriptionSevere Infection Research Group Health Research Institute La Fe-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCell Biology Unit Health Research Institute La Fe-
Descrição: dc.descriptionDepartment of Pathological Anatomy La Fe Hospital-
Descrição: dc.descriptionDepartment of Microbiology and Ecology University of Valencia-
Descrição: dc.descriptionDepartment of Medical Microbiology University and Polytechnic La Fe Hospital-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstituto de Salud Carlos III: JR21/00061-
Idioma: dc.languageen-
Relação: dc.relationPathogens-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCandida auris-
Palavras-chave: dc.subjectemerging infections-
Palavras-chave: dc.subjectGalleria mellonella-
Palavras-chave: dc.subjectmicafungin-
Palavras-chave: dc.subjectnanoemulsion-
Título: dc.titleSunflower Oil and Cholesterol Nanoemulsion: A Novel Carrier for Micafungin to Combat Multi-Resistant Candida auris-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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