Bacterial nanocellulose/calcium alginate hydrogel for the treatment of burns

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Autor(es): dc.contributorGraduate Program in Biomedical Sciences-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBioPolymer and Biomaterial Laboratory-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorGraduate Program in Science of Health-
Autor(es): dc.contributorGraduate Program of Orthodontics-
Autor(es): dc.creatorMunhoz, Lauriene Luiza de Souza-
Autor(es): dc.creatorGuillens, Luiz Carlos-
Autor(es): dc.creatorAlves, Beatriz Candido-
Autor(es): dc.creatorDo Nascimento, Maria Gabriela Oliveira Ferreira-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorCarbinatto, Fernanda Mansano-
Autor(es): dc.creatorArruda, Gabriela-
Autor(es): dc.creatorBarud, Hernane da Silva-
Autor(es): dc.creatorde Aro, Andrea-
Autor(es): dc.creatorCasagrande, Laura de Roch-
Autor(es): dc.creatorSilveira, Paulo Cesar Lock-
Autor(es): dc.creatorAndrade, Thiago Antônio Moretti-
Autor(es): dc.creatorDos Santos, Glaucia Maria Tech-
Autor(es): dc.creatorCaetano, Guilherme Ferreira-
Data de aceite: dc.date.accessioned2025-08-21T17:28:53Z-
Data de disponibilização: dc.date.available2025-08-21T17:28:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/acb393324-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298555-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298555-
Descrição: dc.descriptionPurpose: Bacterial cellulose (BC) has shown high capacity for the treatment of wounds and burns, providing a moisty environment. Calcium alginate can be associated with BC to create gels that aid in wound debridement and contribute to appropriate wound healing. This study is aimed at characterizing and evaluating the use of bacterial cellulose/alginate gel in skin burns in rats. Methods: Cellulose and cellulose/alginate gels were compared regarding the capacity of liquid absorption, moisture, viscosity, and potential cytotoxicity. The 2nd degree burns were produced using an aluminum metal plate (2.0cm) at 120ºC for 20s on the back of rats. The animals were divided into non-treated, CMC(Carboxymethylcellulose), Cellulose(CMC with bacterial cellulose), and Cellulose/alginate(CMC with bacterial cellulose and alginate). The animals received topical treatment 3 times/week. Biochemical (MPO, NAG and oxidative stress), histomorphometry and immunohistochemical assays (IL-1β IL-10 and VEGF) were conducted on the 14th, 21st, 28th, and 35th days. Results: Cellulose/Alginate gel showed higher absorption capacity and viscosity compared to Cellulose gel, with no cytotoxic effects. Cellulose/alginate presented lower MPO values, a higher percentage of IL-10, with greater and balanced oxidative stress profile. Conclusion: The use of cellulose/alginate gel reduced neutrophils and macrophage activation and showed greater anti-inflammatory response, which can contribute to healing chronic wounds and burns.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCentro Universitário Herminio Ometto de Araras Graduate Program in Biomedical Sciences, SP-
Descrição: dc.descriptionUniversidade Estadual de São Paulo School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionUniversidade de Araraquara BioPolymer and Biomaterial Laboratory, SP-
Descrição: dc.descriptionUniversidade de São Paulo Institute of Physics, SP-
Descrição: dc.descriptionUniversidade do Extremo Sul Catarinense Graduate Program in Science of Health, SC-
Descrição: dc.descriptionCentro Universitário Herminio Ometto de Araras Graduate Program of Orthodontics, SP-
Descrição: dc.descriptionUniversidade de São Paulo Ribeirão Preto Medical School, SP-
Descrição: dc.descriptionUniversidade Estadual de São Paulo School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionFAPESP: 2021/11965-3-
Descrição: dc.descriptionCNPq: 309614/2021-0-
Descrição: dc.descriptionCNPq: 406973/2022-9-
Idioma: dc.languageen-
Relação: dc.relationActa Cirurgica Brasileira-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlginates-
Palavras-chave: dc.subjectAnti-Inflammatory Agents-
Palavras-chave: dc.subjectBurns-
Palavras-chave: dc.subjectCellulose-
Palavras-chave: dc.subjectHydrogels-
Título: dc.titleBacterial nanocellulose/calcium alginate hydrogel for the treatment of burns-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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