Antifungal activity of cyclopaldic acid from Antarctic Penicillium against phytopathogenic fungi

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorVieira, Gabrielle-
Autor(es): dc.creatorSette, Lara Durães-
Autor(es): dc.creatorde Angelis, Derlene Attili-
Autor(es): dc.creatorSass, Daiane Cristina-
Data de aceite: dc.date.accessioned2025-08-21T19:33:55Z-
Data de disponibilização: dc.date.available2025-08-21T19:33:55Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s13205-023-03792-9-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298511-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298511-
Descrição: dc.descriptionPlant pathogens cause great economic losses in agriculture. To reduce damage, chemical pesticides have been frequently used, but these compounds in addition to causing risks to the environment and health, its continuous use has given rise to resistant phytopathogens, threatening the efficiency of control methods. One alternative for such a problem is the use of natural products with high antifungal activity and low toxicity. Here, we present the production, isolation, and identification of cyclopaldic acid, a bioactive compound produced by Penicillium sp. CRM 1540, a fungal strain isolated from Antarctic marine sediment. The crude extract was fractionated by reversed-phase chromatography and yielded 40 fractions, from which fraction F17 was selected. We used 1D and 2D Nuclear Magnetic Resonance analysis in DMSO-d6 and CDCl3, together with mass spectrometry, to identify the compound as cyclopaldic acid C11H10O6 (238 Da). The pure compound was evaluated for antimicrobial activity against phytopathogenic fungi of global agricultural importance, namely: Macrophomina phaseolina, Rhizoctonia solani, and Sclerotinia sclerotiorum. The antifungal assay revealed the potential of cyclopaldic acid, produced by Penicillium sp. CRM 1540, as a leading molecule against M. phaseolina and R. solani, with more than 90% of growth inhibition after 96h of contact with the fungal cells using 100 µg mL−1, and more than 70% using 50 µg mL−1.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of General and Applied Biology Institute of Biosciences São Paulo State University Campus Rio Claro, Av. 24-A, 1515, São Paulo-
Descrição: dc.descriptionDivision of Microbial Resources CPQBA University of Campinas, Cidade Universitária “Zeferino Vaz”, São Paulo-
Descrição: dc.descriptionDepartment of General and Applied Biology Institute of Biosciences São Paulo State University Campus Rio Claro, Av. 24-A, 1515, São Paulo-
Descrição: dc.descriptionCNPq: 141988/2018-5-
Descrição: dc.descriptionFAPESP: 2016/07957-7-
Descrição: dc.descriptionFAPESP: 2018/11747-3-
Descrição: dc.descriptionCAPES: 88887.467270/2019-00-
Idioma: dc.languageen-
Relação: dc.relation3 Biotech-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCyclopaldic acid-
Palavras-chave: dc.subjectMacrophomina phaseolina-
Palavras-chave: dc.subjectPenicillium-
Palavras-chave: dc.subjectRhizoctonia solani-
Palavras-chave: dc.subjectSclerotinia sclerotiorum-
Título: dc.titleAntifungal activity of cyclopaldic acid from Antarctic Penicillium against phytopathogenic fungi-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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