In-Hospital influenza vaccination to prevent cardiorespiratory events in the first 45 days after acute coronary syndrome: A prespecified analysis of the VIP-ACS trial

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Autor(es): dc.contributorHospital Israelita Albert Einstein-
Autor(es): dc.contributorHarvard Medical School-
Autor(es): dc.contributorPronto Socorro Cardiológico de Pernambuco PROCAPE-
Autor(es): dc.contributorHospital Santa Lúcia-
Autor(es): dc.contributorHospital Ana Nery-
Autor(es): dc.contributorHospital Regional Hans Dieter Schmidt-
Autor(es): dc.contributorHospital Universitário Ciências Médicas-
Autor(es): dc.contributorInstituto de Pesquisas Médicas de Itajaí-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHospital São Lucas da PUCRS-
Autor(es): dc.contributorIrmandade da Santa Casa de Misericórdia de Marilia-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do Rio Grande do Sul-
Autor(es): dc.contributorCentro de Pesquisa Clínica do Coração-
Autor(es): dc.contributorInstituto Estadual de Cardiologia Aloysio de Castro-
Autor(es): dc.creatorFonseca, Henrique Andrade R.-
Autor(es): dc.creatorZimerman, André-
Autor(es): dc.creatorMonfardini, Frederico-
Autor(es): dc.creatorGuimarães, Hélio Penna-
Autor(es): dc.creatorPedrosa, Rodrigo P.-
Autor(es): dc.creatorPatriota, Rodrigo de Lemos S.-
Autor(es): dc.creatorCouto Patriota, Tarcya L.G.-
Autor(es): dc.creatorPassos, Luiz Carlos Santana-
Autor(es): dc.creatorDall'Orto, Frederico Toledo Campo-
Autor(es): dc.creatorHoffmann Filho, Conrado Roberto-
Autor(es): dc.creatorNascimento, Bruno Ramos-
Autor(es): dc.creatorBaldissera, Felipe Antônio-
Autor(es): dc.creatorPereira, Cesar A.C.-
Autor(es): dc.creatorCaramori, Paulo Ricardo Avancini-
Autor(es): dc.creatorAndrade, Pedro Beraldo-
Autor(es): dc.creatorOkoshi, Marina Politi-
Autor(es): dc.creatorPolanczyk, Carisi Anne-
Autor(es): dc.creatorSilveira, Fabio Serra-
Autor(es): dc.creatorVillacorta, Aline Sterque-
Autor(es): dc.creatorNicolau, José Carlos-
Autor(es): dc.creatorRizzo, Luiz V.-
Autor(es): dc.creatorBerwanger, Otávio-
Data de aceite: dc.date.accessioned2025-08-21T23:31:20Z-
Data de disponibilização: dc.date.available2025-08-21T23:31:20Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-24-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.vaccine.2023.12.074-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298457-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298457-
Descrição: dc.descriptionBackground: Influenza vaccination prevents major cardiovascular events in individuals presenting a recent acute coronary syndrome (ACS), however the early effect of an in-hospital double-dose vaccination strategy remains uncertain. Methods: The VIP-ACS was a randomized, pragmatic, multicenter, open-label trial with a blinded-adjudication endpoint. Patients with ACS ≤ 7 days of hospitalization were randomized to an in-hospital double-dose quadrivalent inactivated influenza vaccine (double-dose) or a standard-dose influenza vaccine at 30 days post-randomization. The primary endpoint was a hierarchical composite of death, myocardial infarction, stroke, hospitalization for unstable angina, hospitalization for heart failure, urgent coronary revascularization, and hospitalization for respiratory infections, analyzed with the win ratio (WR) method in short-term follow-up (45-days after randomization). Results: The trial enrolled 1,801 patients (≥18 years old). Median participant age was 57 years, 70 % were male. There were no significant differences between groups on the primary hierarchical endpoint: there were 5.7 % wins in the double-dose in-hospital group and 5.5 % wins in the standard-dose delayed vaccination group (WR: 1.03; 95 % CI: 0.70–––1.53; P = 0.85). In a sensitivity analysis including COVID-19 infection in the hospitalizations for respiratory infections endpoint, overall results were maintained (WR: 1.03; 95 % CI 0.71–––1.51; P = 0.87). Results were consistent for major cardiovascular events only (WR: 0.82; 95 % CI: 0.48–––1.39; P = 0.46). No serious adverse events were observed. Conclusion: In patients with recent ACS, in-hospital double-dose influenza vaccination did not significantly reduce cardiorespiratory events at 45 days compared with standard-dose vaccination at 30 days post-randomization.-
Descrição: dc.descriptionInstituto Israelita de Ensino e Pesquisa Hospital Israelita Albert Einstein-
Descrição: dc.descriptionTIMI Study Group Brigham and Women's Hospital Harvard Medical School-
Descrição: dc.descriptionPronto Socorro Cardiológico de Pernambuco PROCAPE-
Descrição: dc.descriptionHospital Santa Lúcia-
Descrição: dc.descriptionHospital Ana Nery-
Descrição: dc.descriptionHospital Regional Hans Dieter Schmidt-
Descrição: dc.descriptionHospital Universitário Ciências Médicas-
Descrição: dc.descriptionInstituto de Pesquisas Médicas de Itajaí-
Descrição: dc.descriptionInstituto do Coração (InCor) Hospital das Clínicas Faculdade de Medicina Universidade de São Paulo-
Descrição: dc.descriptionHospital São Lucas da PUCRS-
Descrição: dc.descriptionIrmandade da Santa Casa de Misericórdia de Marilia-
Descrição: dc.descriptionBotucatu Medical School Sao Paulo State University-
Descrição: dc.descriptionHospital de Clínicas de Porto Alegre Universidade Federal do Rio Grande do Sul-
Descrição: dc.descriptionCentro de Pesquisa Clínica do Coração-
Descrição: dc.descriptionInstituto Estadual de Cardiologia Aloysio de Castro-
Descrição: dc.descriptionBotucatu Medical School Sao Paulo State University-
Formato: dc.format496-504-
Idioma: dc.languageen-
Relação: dc.relationVaccine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute coronary syndrome-
Palavras-chave: dc.subjectInfluenza vaccine-
Palavras-chave: dc.subjectMortality-
Palavras-chave: dc.subjectMyocardial infarction-
Palavras-chave: dc.subjectStroke-
Título: dc.titleIn-Hospital influenza vaccination to prevent cardiorespiratory events in the first 45 days after acute coronary syndrome: A prespecified analysis of the VIP-ACS trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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