Maternal–fetal safety evaluation of an aqueous extract of Casearia sylvestris leaves in rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.contributorUniversidade Estadual de Mato Grosso do Sul (UEMS)-
Autor(es): dc.creatorNagaoka, Livia Trippe-
Autor(es): dc.creatorJorge, Bárbara Campos-
Autor(es): dc.creatorStein, Júlia-
Autor(es): dc.creatorManoel, Beatriz de Matos-
Autor(es): dc.creatorValente, Leticia Cardoso-
Autor(es): dc.creatorde Toledo, Laura Leonel-
Autor(es): dc.creatorde Castro, Thiago Luis Aguayo-
Autor(es): dc.creatorKassuya, Cândida Aparecida Leite-
Autor(es): dc.creatorCardoso, Claudia Andrea Lima-
Autor(es): dc.creatorArena, Arielle Cristina-
Data de aceite: dc.date.accessioned2025-08-21T16:20:52Z-
Data de disponibilização: dc.date.available2025-08-21T16:20:52Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/bdr2.2257-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298413-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298413-
Descrição: dc.descriptionBackground: This study evaluated the maternal, embryotoxic, and teratogenic effects of the aqueous extract of Casearia sylvestris (AECS), a species listed in the Unique Health System of Brazil, and widely used for treating several conditions, such as diarrhea, wounds, pain, and ulcers. Methods: Pregnant rats were daily treated orally with 0, 175, 350, or 700 mg/kg/body weight of AECS, from gestational day (GD) 6 to 15 (organogenesis period). On GD 20, the pregnant rats were euthanized, and the litters submitted to an assessment of fetal development. Results: No clinical signs of toxicity were observed in the dams during the treatment. In the embryo-fetal development study, a significant increase in the basal zone height of the placenta was observed in the intermediate dose group. Furthermore, there was a significant increase in the relative anogenital distance measurement of female fetuses in the lowest and intermediate dose groups. Although no visceral abnormalities were observed in the treated-fetuses, skeletal anomalies evidenced by changes in the ossification of the sternum and the presence of supernumerary ribs were found in the intermediate and high dose groups. Conclusion: In conclusion, the treatment with AECS during organogenesis at this dose level had detrimental effects on the normal development of fetuses.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista – UNESP, São Paulo-
Descrição: dc.descriptionCollege of Health Science Federal University of Grande Dourados, Mato Grosso do Sul-
Descrição: dc.descriptionCenter of Studies in Natural Resources State University of Mato Grosso do Sul (UEMS), Mato Grosso do Sul-
Descrição: dc.descriptionToxicological Information and Assistance Center (CIATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista – UNESP, São Paulo-
Descrição: dc.descriptionToxicological Information and Assistance Center (CIATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP), São Paulo-
Formato: dc.format1899-1911-
Idioma: dc.languageen-
Relação: dc.relationBirth Defects Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectmedicinal plants-
Palavras-chave: dc.subjectpregnancy-
Palavras-chave: dc.subjectrats-
Palavras-chave: dc.subjectsafety-
Palavras-chave: dc.subjectskeletal abnormalities-
Palavras-chave: dc.subjectteratogenicity-
Título: dc.titleMaternal–fetal safety evaluation of an aqueous extract of Casearia sylvestris leaves in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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