Cardiac dysfunction in sucrose-fed rats is associated with alterations of phospholamban phosphorylation and TNF-α levels

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.contributorAtenas College-
Autor(es): dc.creatorGregolin, Cristina Schmitt-
Autor(es): dc.creatordo Nascimento, Milena-
Autor(es): dc.creatorde Souza, Sérgio Luiz Borges-
Autor(es): dc.creatorMota, Gustavo Augusto Ferreira-
Autor(es): dc.creatorLuvizotto, Renata de Azevedo Melo-
Autor(es): dc.creatorSugizaki, Mário Mateus-
Autor(es): dc.creatorBazan, Silméia Garcia Zanati-
Autor(es): dc.creatorde Campos, Dijon Henrique Salomé-
Autor(es): dc.creatorCamacho, Camila Renata Corrêa-
Autor(es): dc.creatorCicogna, Antonio Carlos-
Autor(es): dc.creatordo Nascimento, André Ferreira-
Data de aceite: dc.date.accessioned2025-08-21T18:30:30Z-
Data de disponibilização: dc.date.available2025-08-21T18:30:30Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2024.112236-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298409-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298409-
Descrição: dc.descriptionIntroduction: High sucrose intake is linked to cardiovascular disease, a major global cause of mortality worldwide. Calcium mishandling and inflammation play crucial roles in cardiac disease pathophysiology. Objective: Evaluate if sucrose-induced obesity is related to deterioration of myocardial function due to alterations in the calcium-handling proteins in association with proinflammatory cytokines. Methods: Wistar rats were divided into control and sucrose groups. Over eight weeks, Sucrose group received 30% sucrose water. Cardiac function was determined in vivo using echocardiography and in vitro using papillary muscle assay. Western blotting was used to detect calcium handling protein; ELISA assay was used to assess TNF-α and IL-6 levels. Results: Sucrose led to cardiac dysfunction. RYR2, SERCA2, NCX, pPBL Ser16 and L-type calcium channels were unchanged. However, pPBL-Thr17, and TNF-α levels were elevated in the S group. Conclusion: Sucrose induced cardiac dysfunction and decreased myocardial contractility in association with altered pPBL-Thr17 and elevated cardiac pro-inflammatory TNF-α.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Pathology Medical School (FMB) of São Paulo State University (Unesp), Botucatu Campus-
Descrição: dc.descriptionInstitute of Health Sciences Federal University of Mato Grosso (UFMT), Mato Grosso-
Descrição: dc.descriptionDepartment of Medicine Atenas College, Mato Grosso-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu School of Medicine São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionDepartment of Pathology Medical School (FMB) of São Paulo State University (Unesp), Botucatu Campus-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu School of Medicine São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionCNPq: 442979/2014-2-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCalcium handling-
Palavras-chave: dc.subjectCardiac function-
Palavras-chave: dc.subjectDiet-induced obesity-
Palavras-chave: dc.subjectSucrose-
Título: dc.titleCardiac dysfunction in sucrose-fed rats is associated with alterations of phospholamban phosphorylation and TNF-α levels-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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