ASU effect on bone repair in defects grafted with bone substitute

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSection of Oral Radiology-
Autor(es): dc.contributorFaculty of Odontology-
Autor(es): dc.creatorPereira, Lucas de Sousa Goulart-
Autor(es): dc.creatorde PAULA, Luiz Guilherme Freitas-
Autor(es): dc.creatorSpin-Neto, Rubens-
Autor(es): dc.creatorStavropoulos, Andreas-
Autor(es): dc.creatorMarcantonio, Rosemary Adriana Chiérici-
Autor(es): dc.creatorde OLIVEIRA, Guilherme José Pimentel Lopes-
Data de aceite: dc.date.accessioned2025-08-21T22:28:43Z-
Data de disponibilização: dc.date.available2025-08-21T22:28:43Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1807-2577.03524-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298374-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298374-
Descrição: dc.descriptionIntroduction: Grafted areas represent a region of lower biological quality than areas of native bone. Bioactive products can improve bone quality in grafted areas. Objective: To evaluate the effect of avocado/soybean unsaponifiables (ASU) on repair of critical-size calvarial defects (CSDs) filled with osteoconductive bone substitutes Material and method: One CCD (0.5 mm) was made in each of 84 rats. These defects were filled either with coagulum (COA), deproteinized bovine bone (DBB), or tricalcium phosphate/hydroxyapatite (TCP/HA). ASU (0.6 g/kg) or saline solution (CTR) was administered daily by gavage from 15 days before surgery until the animals were euthanized (15 or 60 days after surgery) totaling 7 animals per period/group. The composition of the tissues that filled the CSDs were analyzed by histomorphometric evaluation, while the amount of mineralized tissue was evaluated by micro–CT. Result: The bone filling in COA-ASU group was significantly higher than in the COA-CTR group (46.40 ±10.41% vs. 29.00 ± 8.81% at 15 days and 52.14 ± 6.12% vs. 42.71 ± 5.21% at 60 days) (p<0.05). There were no differences regarding the bone fill between the ASU and CTR groups in DBB and HA/TCP grafted CSDs. There were higher amount of mineralized tissues in the CSDs of the CTR groups than the ASU groups at 15 days (66.73 ± 6.70% vs. 52.25 ± 9.71% in DBB grafted CSDs and 53.16 ± 10.08% vs. 37.95 ± 4.70% in HA/TCP grafted CSDs) (p<0.05). Conclusion: ASU enhanced the bone repair in the CSDs filled with COA; however, this positive effect was not seen in DBB or HA/TCP grafted CSDs.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUFU – Universidade Federal de Uberlândia Faculdade de Odontologia de Uberlândia Departamento de Periodontia, MG-
Descrição: dc.descriptionUNESP – Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Odontologia de Araraquara Departamento de Diagnostico e Cirurgia, SP-
Descrição: dc.descriptionAarhus University Department of Dentistry Section of Oral Radiology-
Descrição: dc.descriptionMalmo University Faculty of Odontology Department of Periodontology and Community Dentistry-
Descrição: dc.descriptionUNESP – Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Odontologia de Araraquara Departamento de Diagnostico e Cirurgia, SP-
Descrição: dc.descriptionFAPESP: 2009/17395-2-
Descrição: dc.descriptionFAPESP: 2010/13029-9-
Idioma: dc.languageen-
Relação: dc.relationRevista de Odontologia da UNESP-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectASU-
Palavras-chave: dc.subjectbiomaterial-
Palavras-chave: dc.subjectbone healing-
Palavras-chave: dc.subjectcritical-sized calvarial defects-
Palavras-chave: dc.subjecthistomorphometry-
Palavras-chave: dc.subjectmicro CT-
Título: dc.titleASU effect on bone repair in defects grafted with bone substitute-
Título: dc.titleEfeito do ASU no reparo ósseo de defeitos enxertados com substituto ósseo-
Tipo de arquivo: dc.typelivro digital-
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