Influence of maternal hyperglycemia on placental capillary distribution

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHuntington Medicina Reprodutiva-Eugin Group-
Autor(es): dc.creatorMoreli, Jusciele Brogin-
Autor(es): dc.creatorFerrari, Natália-
Autor(es): dc.creatorRuocco, Ana Maria Cirino-
Autor(es): dc.creatorSantos, Mariana Gomes de Oliveira-
Autor(es): dc.creatorLorenzon, Aline Rodrigues-
Autor(es): dc.creatorCarlos, Carla Patrícia-
Autor(es): dc.creatorRudge, Marilza Vieira Cunha-
Autor(es): dc.creatorCalderon, Iracema de Mattos Paranhos-
Data de aceite: dc.date.accessioned2025-08-21T21:16:54Z-
Data de disponibilização: dc.date.available2025-08-21T21:16:54Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.31744/einstein_journal/2024AO0583-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298369-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298369-
Descrição: dc.descriptionOBJECTIVE: This study was conducted to investigate the distribution of placental villous vessels in pregnant women with different degrees of hyperglycemia. METHODS: A cross-sectional study was performed using placental samples from 30 pregnant women without diabetes (n=10), with gestational diabetes mellitus (n=10), and with previous diabetes (type 1 and type 2 diabetes; n=10). Maternal glycemic control was evaluated using the glycemic mean and glycated hemoglobin levels. Placental samples were obtained during elective cesarean sections and processed for villous vessel analysis using immunohistochemistry for Von Willebrand factor. Vessels within 10μm of the villus margin were classified as peripheral, and vessels at a distance greater than 10μm were classified as central. The number, area, and perimeter of all vessels were evaluated, and the relationship between vessel area and total area of placental villus was calculated. RESULTS: Pregnant women with gestational diabetes mellitus and those with previous diabetes had higher glycated hemoglobin levels. The number of vessels was reduced in the villi of the previous Diabetes Group owing to peripheral reduction. Additionally, the area, perimeter, and percentage of peripheral blood were lower in the previous Diabetes Group than in the Non-Diabetic Group. CONCLUSION: Maternal glycemic levels can modify placental capillary distribution.-
Descrição: dc.descriptionMoreli et al. demonstrated a reduction in vessels in the periphery of the placental villi in pregnant women with previous diabetes (type 1 and type 2). The placental vessels of this population are more distant from the maternal blood and may represent placental villous immaturity. These results were obtained when we classified the villous vessels as central or peripherial using 10μm of the villus margin as a reference.-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculdade de Medicina de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho-
Descrição: dc.descriptionHuntington Medicina Reprodutiva-Eugin Group-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculdade de Medicina de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho-
Formato: dc.formateAO0583-
Idioma: dc.languageen-
Relação: dc.relationEinstein (Sao Paulo, Brazil)-
???dc.source???: dc.sourceScopus-
Título: dc.titleInfluence of maternal hyperglycemia on placental capillary distribution-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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